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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Ace2-ACE2)1Cqin
transgene insertion 1, Chuan Qin
MGI:6401292
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Ace2-ACE2)1Cqin/0 involves: ICR MGI:6402641


Genotype
MGI:6402641
tg1
Allelic
Composition
Tg(Ace2-ACE2)1Cqin/0
Genetic
Background
involves: ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• some lymph nodes from SARS-CoV-infected mice severe hemorrhage
• some lymph nodes from SARS-CoV-infected mice exhibit severe necrosis
• SARS-CoV-infected mice exhibit lymphocytic infiltrate in the submandibular gland
• SARS-CoV-infected mice exhibit pyelitis
• SARS-CoV-infected mice exhibit desquamative pulmonary alveolitis and bronchitis and multinucleated macrophages in the alveoli
• SARS-CoV-infected mice exhibit more severe pulmonary damage accompanied by interstitial hyperemia, edema, inflammatory cell infiltration (both monocytes and lymphocytes), thickened interstitial, broken alveolar walls, extensive consolidation, compensatory emphysema and extensive hemorrhage (J:141460)
• lung tissues from SARS-CoV-2-infected mice show moderate interstitial pneumonia characterized by thickened alveolar septa with infiltration of inflammatory cells in 70-80% areas of lung tissues and accumulation of inflammatory cells in partial alveolar cavities at 3 dpi; pneumonia becomes mild at 7 dpi (J:287631)
• inflammatory cells in SARS-CoV2-infected mice include lymphocytes, macrophages, and neutrophils which accumulate in the alveolar interstitium and cause thickening of the alveolar walls (J:287631)
• lungs of SARS-CoV-2-infected mice show more macrophages, and T lymphocytes, with MAC2+ macrophages diffusely infiltrated in the alveolar cavities or focally aggregated in the thickened alveolar septum, CD3+ T lymphocytes dispersed or aggregated in the alveolar interstitium, and CD19+ B lymphocytes in the alveolar interstitium (J:287631)
• mice show increased susceptibility to infection with human acute respiratory syndrome coronavirus (SARS-CoV) strain PUMC01, showing greater viral titer in lungs than wild-type mice, slower clearing of virus, more severe pathologic changes and systemic toxic reaction (J:141460)
• SARS-CoV antigen is detected in vascular endothelial cells and epithelial cells of the alveoli and in cerebral neurocytes but no virus antigen is detected in the kidney, heart, liver, stomach or other organs (J:141460)
• 7 of 13 non-infected mice housed with SARS-CoV-2/WH-09/human/2020/CHN-infected mice develop antibody seropositivity indicating high risk of close contact transmission (J:288244)
• 3 of 10 naive mice exposed to respiratory droplets from SARS-CoV-2-infected mice via airflow transmission cages show seropositivity 14 days after exposure (J:288244)
• however, mice cannot be infected via aerosol inoculation until continued up to 25 minutes with high virus concentration (J:288244)
• mice show susceptibility to intranasal infection with the SARS-CoV-2 stock virus HB-01 (BetaCoV/Wuhan/IVDC-HB-01/2020|EPI_ISL_402119), with mice showing weight loss of up to 8% at 5 days post infection (dpi) that is not seen in wild-type controls and viral loads detected in lungs with highest virus titers detected at 3 dpi in the lungs (J:287631)
• specific IgG antibodies against S protein of SARS-CoV-2 are detected in the sera of infected mice at 21 dpi (J:287631)
• viral antigens are detected within alveolar macrophages, alveolar epithelia, and degenerative/desquamated bronchial epithelial cells of SARS-CoV-2-infected mice (J:287631)
• small amounts of viral antigens are detected in respiratory epithelial cells within non-lesional areas of the lungs (J:287631)
• infectious virus is isolated from the lungs at 1, 3, and 5 dpi, with highest viral titers at 3 dpi (J:287631)
• however, no lesions or viral antigens are seen in the myocardium, liver, spleen, kidney, cerebrum, intestine and testis of SARS-CoV-2-infected mice (J:287631)

growth/size/body
• SARS-CoV-2-infected mice show weight loss, with up to 8% weight loss at 5 dpi

respiratory system
• SARS-CoV-infected mice exhibit extensive hemorrhage in the lungs at 3 days post infection
• SARS-CoV-infected mice exhibit interstitial hyperemia
• SARS-CoV-infected mice exhibit desquamative pulmonary alveolitis and bronchitis and multinucleated macrophages in the alveoli
• SARS-CoV-infected mice exhibit more severe pulmonary damage accompanied by interstitial hyperemia, edema, inflammatory cell infiltration (both monocytes and lymphocytes), thickened interstitial, broken alveolar walls, extensive consolidation, compensatory emphysema and extensive hemorrhage (J:141460)
• lung tissues from SARS-CoV-2-infected mice show moderate interstitial pneumonia characterized by thickened alveolar septa with infiltration of inflammatory cells in 70-80% areas of lung tissues and accumulation of inflammatory cells in partial alveolar cavities at 3 dpi; pneumonia becomes mild at 7 dpi (J:287631)
• inflammatory cells in SARS-CoV2-infected mice include lymphocytes, macrophages, and neutrophils which accumulate in the alveolar interstitium and cause thickening of the alveolar walls (J:287631)
• lungs of SARS-CoV-2-infected mice show more macrophages, and T lymphocytes, with MAC2+ macrophages diffusely infiltrated in the alveolar cavities or focally aggregated in the thickened alveolar septum, CD3+ T lymphocytes dispersed or aggregated in the alveolar interstitium, and CD19+ B lymphocytes in the alveolar interstitium (J:287631)
• SARS-CoV-2-infected mice develop gross lesions with focal to multifocal dark red discoloration in lung lobes at 3 dpi that progress to multifocal to coalescent scattered-dark reddish purple areas and focal nodules throughout the lungs at 5 dpi and damaged lungs become swollen and enlarged
• SARS-CoV-infected mice exhibit more severe pulmonary edema than infected wild-type mice
• SARS-CoV-2-infected mice show thickened alveolar interstitium wtih increased collagen fibers at 5 dpi
• SARS-CoV-infected mice exhibit compensatory emphysema at 3 days post infection
• detached bronchiolar epithelium is occasionally seen in affected bronchioles at 5 dpi with SARS-CoV-2
• bronchiolar epithelial cells from SARS-CoV-2-infected mice show swelling and degeneration

cardiovascular system
• SARS-CoV-infected mice exhibit dilated and engorged glomerular capillaries
• some blood vessels become degenerated in SARS-CoV-infected mice
• mild lymphocytic infiltration and sarcolemmal proliferation are present in cardiac interstitital tissue
• SARS-CoV-infected mice exhibit extensive hemorrhage in the lungs at 3 days post infection
• SARS-CoV-infected mice exhibit interstitial hyperemia
• SARS-CoV-infected mice show brain hemorrhage
• some lymph nodes from SARS-CoV-infected mice severe hemorrhage
• SARS-CoV-infected mice show brain vasculitis

cellular
• SARS-CoV-infected mice exhibit patchy necrosis in the liver
• some lymph nodes from SARS-CoV-infected mice exhibit severe necrosis

digestive/alimentary system
• mucosal layers of the small intestine of SARS-CoV-infected mice show signs of edema, small vessel dilation, and lymphocyte infiltration
• mucosal layers of the stomach of SARS-CoV-infected mice show signs of edema, small vessel dilation, and lymphocyte infiltration
• SARS-CoV-infected mice exhibit lymphocytic infiltrate in the submandibular gland

homeostasis/metabolism
• SARS-CoV-infected mice exhibit more severe pulmonary edema than infected wild-type mice

liver/biliary system
• SARS-CoV-infected mice exhibit patchy necrosis in the liver

nervous system
• SARS-CoV-infected mice show brain hemorrhage
• SARS-CoV-infected mice exhibit brain damage including ependymitis, vasculitis, and hemorrhage

renal/urinary system
• SARS-CoV-infected mice exhibit dilated and engorged glomerular capillaries
• SARS-CoV-infected mice exhibit pyelitis
• SARS-CoV-infected mice show degeneration of proximal tubule epithelial cells
• SARS-CoV-infected mice show lymphocytic infiltrate in the renal interstitia

endocrine/exocrine glands
• SARS-CoV-infected mice exhibit lymphocytic infiltrate in the submandibular gland

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
COVID-19 DOID:0080600 J:287631 , J:288244
severe acute respiratory syndrome DOID:2945 J:141460





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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory