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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Stk38ltm1b(KOMP)Wtsi
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:6356401
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Stk38ltm1b(KOMP)Wtsi/Stk38ltm1b(KOMP)Wtsi B6J.B6N(FVB)-Stk38ltm1b(KOMP)Wtsi MGI:6356897


Genotype
MGI:6356897
hm1
Allelic
Composition
Stk38ltm1b(KOMP)Wtsi/Stk38ltm1b(KOMP)Wtsi
Genetic
Background
B6J.B6N(FVB)-Stk38ltm1b(KOMP)Wtsi
Cell Lines EPD0396_5_A05
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk38ltm1b(KOMP)Wtsi mutation (0 available); any Stk38l mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• young mice exhibit normal ERG and visual placement responses
• adult mice exhibit normal inner and outer nuclear layer thickness
• mice exhibit normal distribution of horizontal and bipolar cells as well as Mueller cell proliferation
• opsin is mislocalized to the inner segments, the perinuclear cytoplasm in the outer nuclear layer and the rod synaptic terminals in the outer plexiform layer
• amacrine cell interneuron organization is disrupted with localization of Pax6+ cells throughout the inner nuclear layer
• increased cellular proliferation in the inner nuclear layer and retinal ganglion layer, likely interneuron cells
• increased amacrine cell proliferation with reduced mature amacrine cell marker expression
• of interneurons in the inner nuclear layer

nervous system
• amacrine cell interneuron organization is disrupted with localization of Pax6+ cells throughout the inner nuclear layer

cellular
• of interneurons in the inner nuclear layer





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory