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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Opalintm1Tfr
targeted mutation 1, Teiichi Furuichi
MGI:6322964
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Opalintm1Tfr/Opalintm1Tfr B6.129P2-Opalintm1Tfr MGI:6359784


Genotype
MGI:6359784
hm1
Allelic
Composition
Opalintm1Tfr/Opalintm1Tfr
Genetic
Background
B6.129P2-Opalintm1Tfr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opalintm1Tfr mutation (0 available); any Opalin mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• male mice show normal basic sensory and motor activities with no differences in sensory reflex, circadian rhythm, locomotor activity in the home cage, anxiety- or depression-like behavior relative to wild-type controls
• no epilepsy-like phenotypes are observed under ordinary breeding conditions
• in the open-field test, male mice are more active in the first 5 min and spend more time in the center area relative to wild-type controls
• however, no significant differences are observed in the light/dark transition

nervous system
N
• surprisingly, mice show no apparent differences in CNS myelination and oligodendrocyte maturation
• optic nerves are normal in terms of fine structures of paranodal loops, transverse bands, and multi-lamellae of myelinated axons

growth/size/body
N
• mice grow normally with no differences in body shape and weight relative to wild-type controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory