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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dennd5bem1Smgo
endonuclease-mediated mutation 1, Scott M Gordon
MGI:6317361
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dennd5bem1Smgo/Dennd5bem1Smgo involves: C57BL/6 * CBA MGI:6317390


Genotype
MGI:6317390
hm1
Allelic
Composition
Dennd5bem1Smgo/Dennd5bem1Smgo
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dennd5bem1Smgo mutation (0 available); any Dennd5b mutation (179 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• distended small intestine on normal chow (20% increase in luminal surface)
• whitish color on standard chow
• massive lipid accumulation in duodenum enterocytes on standard chow
• massive lipid accumulation in duodenum enterocytes on standard chow
• lower secretion of apoB into lacteal on standard chow
• distended small intestine on standard chow (20% increase in luminal surface)
• distended small intestine on standard chow (20% increase in luminal surface)
• distended small intestine on standard chow (20% increase in luminal surface)
• distended small intestine on standard chow (20% increase in luminal surface)
• higher fecal mass after 4 months on Western Diet
• significantly increased fecal free fatty acid levels after 4 months on Western Diet
• fecal total cholesterol and triglyceride content after 4 months on Western Diet
• very few fusion events between chylomicron secretory vesicles and plasma membrane and very few extracellular chylomicrons in enterocytes at 1 h. after oral oil gavage
• accumulation of vesicle-bound chylomicrons and some lipid droplets in enterocytes at 2 h. after oral oil gavage

homeostasis/metabolism
• 30% reduction in plasma total cholesterol (TC
• resistance to plasma total cholesterol (TC) and phospholipids (PL) level increases after 4 months on Western Diet
• resistance to increase in HDL levels and accumulation of larger-sized cholesterol-rich lipoprotein after 4 months on Western Diet
• normal plasma phospholipids (PL) and triglyceride (TG) levels
• 30% reduction in plasma total cholesterol (TC) (J:276600)
• 22% reduction in total HDL particle number due to reduction in medium sized particles (J:276600)
• normal large HDL particle number (J:276600)
• 20% reduction in plasma total cholesterol (TC) (J:276600)
• 21% increase after intravenous tyloxapol injection after 4 months on Western Diet
• significantly reduced after 4 months on Western Diet
• significantly reduced after 4 months on Western Diet

growth/size/body
• lower fat mass after 4 months on Western Diet
• lower fat mass and higher lean mass after 4 months on Western Diet
• higher lean mass after 4 months on Western Diet
• 50% reduction in body weight gain rate after 1 month on Western Diet
• reduced body weight gain: 30% lower than wild-type body weight after 4 months on Western Diet
• normal bodyweight on standard chow

liver/biliary system
• significantly reduced after 4 months on Western Diet
• significantly reduced after 4 months on Western Diet

cardiovascular system
• significantly lower plaque burden after 4 months on Western Diet

adipose tissue
• lower fat mass after 4 months on Western Diet





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/28/2022
MGI 6.20
The Jackson Laboratory