Phenotypes associated with this allele

• Allele Symbol: Dennd5b^em1Smgo
• Allele Name: endonuclease-mediated mutation 1, Scott M Gordon
• Allele ID: MGI:6317361
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dennd5b^em1Smgo/Dennd5b^em1Smgo	involves: C57BL/6 * CBA	MGI:6317390

Genotype
MGI:6317390

hm1

• Allelic Composition: Dennd5b^em1Smgo/Dennd5b^em1Smgo
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal small intestine morphology ( J:276600 )

♀ • distended small intestine on normal chow (20% increase in luminal surface)

♀ • whitish color on standard chow

♀ • massive lipid accumulation in duodenum enterocytes on standard chow

abnormal duodenum morphology ( J:276600 )

♀ • massive lipid accumulation in duodenum enterocytes on standard chow

♀ • lower secretion of apoB into lacteal on standard chow

distended duodenum ( J:276600 )

♀ • distended small intestine on standard chow (20% increase in luminal surface)

distended ileum ( J:276600 )

♀ • distended small intestine on standard chow (20% increase in luminal surface)

distended jejunum ( J:276600 )

♀ • distended small intestine on standard chow (20% increase in luminal surface)

increased small intestine length ( J:276600 )

♀ • distended small intestine on standard chow (20% increase in luminal surface)

abnormal digestive system physiology ( J:276600 )

♀ • higher fecal mass after 4 months on Western Diet

♀ • significantly increased fecal free fatty acid levels after 4 months on Western Diet

♀ • fecal total cholesterol and triglyceride content after 4 months on Western Diet

abnormal intestine physiology ( J:276600 )

♀ • very few fusion events between chylomicron secretory vesicles and plasma membrane and very few extracellular chylomicrons in enterocytes at 1 h. after oral oil gavage

♀ • accumulation of vesicle-bound chylomicrons and some lipid droplets in enterocytes at 2 h. after oral oil gavage

homeostasis/metabolism

abnormal circulating lipid level ( J:276600 )

♀ • 30% reduction in plasma total cholesterol (TC

♀ • resistance to plasma total cholesterol (TC) and phospholipids (PL) level increases after 4 months on Western Diet

♀ • resistance to increase in HDL levels and accumulation of larger-sized cholesterol-rich lipoprotein after 4 months on Western Diet

♀ • normal plasma phospholipids (PL) and triglyceride (TG) levels

decreased circulating HDL cholesterol level ( J:276600 , J:276600 )

♀ • 30% reduction in plasma total cholesterol (TC) (J:276600)

♀ • 22% reduction in total HDL particle number due to reduction in medium sized particles (J:276600)

♀ • normal large HDL particle number (J:276600)

♂ • 20% reduction in plasma total cholesterol (TC) (J:276600)

increased circulating VLDL triglyceride level ( J:276600 )

♀ • 21% increase after intravenous tyloxapol injection after 4 months on Western Diet

decreased liver cholesterol level ( J:276600 )

♀ • significantly reduced after 4 months on Western Diet

decreased liver free fatty acids level ( J:276600 )

♀ • significantly reduced after 4 months on Western Diet

growth/size/body

decreased body fat mass ( J:276600 )

♀ • lower fat mass after 4 months on Western Diet

abnormal body mass index ( J:276600 )

♀ • lower fat mass and higher lean mass after 4 months on Western Diet

increased lean body mass ( J:276600 )

♀ • higher lean mass after 4 months on Western Diet

decreased susceptibility to weight gain ( J:276600 )

♀ • 50% reduction in body weight gain rate after 1 month on Western Diet

♀ • reduced body weight gain: 30% lower than wild-type body weight after 4 months on Western Diet

♀ • normal bodyweight on standard chow

liver/biliary system

decreased liver cholesterol level ( J:276600 )

♀ • significantly reduced after 4 months on Western Diet

decreased liver free fatty acids level ( J:276600 )

♀ • significantly reduced after 4 months on Western Diet

cardiovascular system

decreased susceptibility to atherosclerosis ( J:276600 )

♀ • significantly lower plaque burden after 4 months on Western Diet

adipose tissue

decreased body fat mass ( J:276600 )

♀ • lower fat mass after 4 months on Western Diet