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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Plcg2em1Msasn
endonuclease-mediated mutation 1, Michael Sasner
MGI:6316314
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Plcg2em1Msasn/Plcg2em1Msasn B6.Cg-Plcg2em1Msasn/J MGI:6741044


Genotype
MGI:6741044
hm1
Allelic
Composition
Plcg2em1Msasn/Plcg2em1Msasn
Genetic
Background
B6.Cg-Plcg2em1Msasn/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2em1Msasn mutation (2 available); any Plcg2 mutation (74 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• enhanced endocytic clearance of amyloid beta 1-42 oligomers and 10 kDa dextran in macrophages and microglia
• reduced phagocytosis of E. Coli and zymosan particles

hematopoietic system
• reduced phagocytosis of E. Coli and zymosan particles

homeostasis/metabolism
• greater increase in intracellular calcium levels in microglia cultured from neonatal cortex and hippocampus after anti-Fcgr2b/3 exposure
• greater increase in intracellular calcium levels in microglia and macrophages after stimulation with LPS or high dose of amyloid beta 1-42 oligomers

immune system
• reduced phagocytosis of E. Coli and zymosan particles





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory