Phenotypes associated with this allele

• Allele Symbol: Nucks1^tm1.2Vter
• Allele Name: targeted mutation 1.2, Vinay Tergaonkar
• Allele ID: MGI:6294929
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nucks1^tm1.2Vter/Nucks1^tm1.2Vter	involves: 129S2/SvPas * C57BL/6 * C57BL/6NSlc * FVB/N * SJL	MGI:6295177

Genotype
MGI:6295177

hm1

• Allelic Composition: Nucks1^tm1.2Vter/Nucks1^tm1.2Vter
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NSlc * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryo phenotype ( J:211777 )

N • mice born at expected Mendelian ratios

adipose tissue

increased total body fat amount ( J:211777 )

• from liver, visceral and subcutaneous fat at age 3 months on normal chow diet

• increased fat amount after 2.5 and 4 months on high fat diet from age 2 months

increased renal fat pad weight ( J:211777 )

• with larger adipocytes on high fat diet

growth/size/body

increased body weight ( J:211777 )

• increased weight gain during 4 months on normal chow diet and high fat diet from age 2 months

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:211777 )

N • normal body temperature

N • normal liver triglyceride and HDL, LDL and VLDL cholesterol levels on high fat diet

N • normal serum leptin, adiponectin, triglyceride and free fatty acid levels on normal chow diet

N • normal resting and fasting glucose levels on normal chow diet

increased circulating glucose level ( J:211777 )

• elevated resting blood glucose level on high fat diet

• normal resting and fasting glucose levels on normal chow diet

increased circulating insulin level ( J:211777 )

• resting plasma insulin levels on normal chow and high fat diet

increased circulating leptin level ( J:211777 )

• on high fat diet

• normal serum leptin on normal chow diet

decreased energy expenditure ( J:211777 )

• at age 3 months on normal chow diet

impaired glucose tolerance ( J:211777 )

• higher blood glucose levels after 30 and 60 minutes in glucose tolerance test (GTT) on normal chow diet

• higher blood glucose levels after 30 minutes in glucose tolerance test (GTT) on high fat diet

insulin resistance ( J:211777 )

• slower reduction of glucose levels after insulin injection on normal chow and high fat diet

decreased circulating adiponectin level ( J:211777 )

• on high fat diet

• normal serum adiponectin on normal chow diet

decreased basal metabolism ( J:211777 )

• at age 3 months on normal chow diet

liver/biliary system

hepatic steatosis ( J:211777 )

• increased lipid levels in liver cytosol on high fat diet

behavior/neurological

increased food intake ( J:211777 )

• at age 3 months on normal chow diet

decreased locomotor activity ( J:211777 )

• reduced locomotor activity during day- and nighttime

respiratory system

increased pulmonary respiratory rate ( J:211777 )

• during daytime at age 3 months on normal chow diet