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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lgi1tm2.1Jkc
targeted mutation 2.1, John K Cowell
MGI:6275636
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lgi1tm2.1Jkc/Lgi1tm2.1Jkc
Pvalbtm1(cre)Arbr/0 		involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:6275804
cn2
 		Lgi1tm2.1Jkc/Lgi1tm2.1Jkc
Tg(CMV-cre)1Cgn/0 		involves: 129/Sv * BALB/cJ * C57BL/6 MGI:6275802
cn3
 		Lgi1tm2.1Jkc/Lgi1tm2.1Jkc
Tg(Camk2a-cre)T29-1Stl/0 		involves: 129/Sv * BALB/cJ * C57BL/6 MGI:6275805
cn4
 		Lgi1tm2.1Jkc/Lgi1tm2.1Jkc
Tg(GFAP-cre)25Mes/0 		involves: 129/Sv * C57BL/6 * FVB/N MGI:6275806
cn5
 		Lgi1tm2.1Jkc/Lgi1tm2.1Jkc
Tg(Nes-cre)1Kln/0 		involves: 129/Sv * C57BL/6 * SJL MGI:6275803


Genotype
MGI:6275804
cn1
Allelic
Composition		 Lgi1tm2.1Jkc/Lgi1tm2.1Jkc
Pvalbtm1(cre)Arbr/0
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgi1tm2.1Jkc mutation (1 available); any Lgi1 mutation (32 available)
Pvalbtm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:269784 )
N
• mice do not develop seizures, cortical dysplasia or hypercellularity in the outer cortical layers




Genotype
MGI:6275802
cn2
Allelic
Composition		 Lgi1tm2.1Jkc/Lgi1tm2.1Jkc
Tg(CMV-cre)1Cgn/0
Genetic
Background		 involves: 129/Sv * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgi1tm2.1Jkc mutation (1 available); any Lgi1 mutation (32 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
seizures ( J:269784 )
• mice develop seizures between P12 and P20

nervous system
seizures ( J:269784 )
• mice develop seizures between P12 and P20
abnormal neocortex morphology ( J:269784 )
• hypercellularity of neuronal cells in layers 2-4




Genotype
MGI:6275805
cn3
Allelic
Composition		 Lgi1tm2.1Jkc/Lgi1tm2.1Jkc
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background		 involves: 129/Sv * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgi1tm2.1Jkc mutation (1 available); any Lgi1 mutation (32 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:269784 )
N
• mice do not develop seizures, cortical dysplasia or hypercellularity in the outer cortical layers




Genotype
MGI:6275806
cn4
Allelic
Composition		 Lgi1tm2.1Jkc/Lgi1tm2.1Jkc
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgi1tm2.1Jkc mutation (1 available); any Lgi1 mutation (32 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:269784 )
N
• mice do not develop seizures, cortical dysplasia or hypercellularity in the outer cortical layers




Genotype
MGI:6275803
cn5
Allelic
Composition		 Lgi1tm2.1Jkc/Lgi1tm2.1Jkc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgi1tm2.1Jkc mutation (1 available); any Lgi1 mutation (32 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
seizures ( J:269784 )
• mice develop seizures between P12 and P20

nervous system
seizures ( J:269784 )
• mice develop seizures between P12 and P20
abnormal neocortex morphology ( J:269784 )
• hypercellularity of neuronal cells in layers 2-4




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory