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Allele Symbol Allele Name Allele ID |
If1l low response MGI:6201402 |
| Summary |
2 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: although the induction of slow-wave sleep in response to influenza is normal but slightly shorter in duration compared with C57BL/6 mice, infection with Newcastle disease virus fails to induce increased slow-wave sleep in this congenic, similar to the non-responsive phenotype found in BALB/c mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Relative to C57BL/6 mice, BALB/c respond to the Kumarov strain of Newcastle disease virus with much lower serum interferon titers and F1 hybrids respond with intermediate titers closer to that of the BALB/c parent than to that of the C57BL/6 parent
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• Relative to C57BL/6 mice, BALB/c respond to the Kumarov strain of Newcastle disease virus with much lower serum interferon titers and F1 hybrids respond with intermediate titers closer to that of the BALB/c parent than to that of the C57BL/6 parent
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• Background Sensitivity: in response to Newcastle disease virus or i.p. injection with polyinosinic: polycytidilic acid, which increases plasma interferon activity and increases slow-wave sleep and decreases locomotor activity in C57BL/6 mice, BALB/c mice do not show increased slow-wave sleep or decreased locomotor activity, nor do they have increased slow-wave sleep in response to intranasal inoculation with influenza virus, which causes increased slow-wave sleep in C57BL/6 mice.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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