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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(RHO*P347S)A1Tili
transgene insertion A1, Tiansen Li
MGI:6187993
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Ntrk3tm1.1Tes/Ntrk3+
Tg(RHO*P347S)A1Tili/0
involves: 129S1/Sv * C57BL/6J * FVB/N MGI:6188005
cx2
Ntrk3tm1.1Tes/Ntrk3tm1.1Tes
Tg(RHO*P347S)A1Tili/0
involves: 129S1/Sv * C57BL/6J * FVB/N MGI:6188007
cx3
Rhotm1Jlem/Rhotm1Jlem
Tg(RHO*P347S)A1Tili/0
involves: 129S4/SvJae * FVB/N MGI:6378570
tg4
Tg(RHO*P347S)A1Tili/0 involves: C57BL/6J * FVB/N MGI:6188004


Genotype
MGI:6188005
cx1
Allelic
Composition
Ntrk3tm1.1Tes/Ntrk3+
Tg(RHO*P347S)A1Tili/0
Genetic
Background
involves: 129S1/Sv * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk3tm1.1Tes mutation (0 available); any Ntrk3 mutation (9 available)
Tg(RHO*P347S)A1Tili mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• as early as P18 to a lesser degree than in Tg(RHO*P347S)#Tili mice until P28
• however, mice exhibit normal nerve fiber, ganglion cell and inner plexiform layer thickness

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:262975




Genotype
MGI:6188007
cx2
Allelic
Composition
Ntrk3tm1.1Tes/Ntrk3tm1.1Tes
Tg(RHO*P347S)A1Tili/0
Genetic
Background
involves: 129S1/Sv * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk3tm1.1Tes mutation (0 available); any Ntrk3 mutation (9 available)
Tg(RHO*P347S)A1Tili mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

vision/eye
• some mice do not open their eye lids normally compared with wild-type mice
• some mice do not open their eye lids normally compared with wild-type mice

growth/size/body
• low-weight offspring




Genotype
MGI:6378570
cx3
Allelic
Composition
Rhotm1Jlem/Rhotm1Jlem
Tg(RHO*P347S)A1Tili/0
Genetic
Background
involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1Jlem mutation (7 available); any Rho mutation (13 available)
Tg(RHO*P347S)A1Tili mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice exhibit a shortened outer segment at 4 weeks of age
• the outer nuclear layer begins to degenerate at 4 weeks of age and is completely degenerated by 24 weeks of age
• severe retinal degeneration at 1 month of age
• 15-fold reduction in a- waves at 4 weeks of age and complete loss of a-waves at 12 weeks of age
• gene therapy with a microRNA sequence that specifically silences the pathogenic human rhodopsin gene and replacement with a rhodopsin that is resistant to this microRNA at P19 results in rescue of visual function
• 3-fold reduction in b-waves at 4 weeks of age and complete loss of b-waves at 12 weeks of age

nervous system
• mice exhibit a shortened outer segment at 4 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:280289




Genotype
MGI:6188004
tg4
Allelic
Composition
Tg(RHO*P347S)A1Tili/0
Genetic
Background
involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• as early as P18
• however, mice exhibit normal nerve fiber, ganglion cell and inner plexiform layer thickness

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:262975





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory