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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atp1a3tm1Ute
targeted mutation 1, Ute Hochgeschwender
MGI:6162645
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Atp1a3tm1Ute/Atp1a3+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:6162678


Genotype
MGI:6162678
ht1
Allelic
Composition
Atp1a3tm1Ute/Atp1a3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a3tm1Ute mutation (0 available); any Atp1a3 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• one of three mice exhibiting spontaneous seizures exhibits premature death
• of three of four mice kindled mice

behavior/neurological
N
• mice exhibit normal cued conditioning, grip strength and tail flick task response
• mice take longer to find a hidden platform or crawl onto a marked platform compared with wild-type mice
• mice exhibit normal grip strength
• mice exhibit equal preference for two identical objects in a novel object task
• in an open field test, mice exhibit increased activity including in the center area compared with wild-type mice
• during the beam-walking task
• severe during the beam-walking task
• mice take longer to cross a beam, exhibit more hindlimb slips, and often use their forelimbs to drag themselves across unlike wild-type mice
• however, mice exhibit normal performance on an accelerated rotarod
• in 15 of 16 mice, predominantly upon exposure to water
• in an open field test, mice exhibit increased activity including in the center area compared with wild-type mice
• reversible hemiplegia or hemiparese in 14 of 35 mice at between 8 and 28 weeks of age often during handling
• hemiplegias become bilateral and alternated within the same spell
• longer latency to response
• spontaneous and recurrent
• reduced latency to seizure onset induced by flurothyl
• longer after discharge duration after achieving the fully kindled state

nervous system
• spontaneous and recurrent
• reduced latency to seizure onset induced by flurothyl
• longer after discharge duration after achieving the fully kindled state
• increased excitability with polyspikes in 5 of 6 mice induced by 30 1 Hz pulses with gradual increase in number of spikes and area, increased area of polyspike in response to paired-pulse stimulation, and larger spreading depression duration and area
• however, the fEPSP slope and amplitude are normal during repetitive stimulation

growth/size/body
N
• mice exhibit normal trunk length
• at 6, 8, 9 and 11 weeks in male mice
• however, female mice exhibit normal weight

muscle
• in 15 of 16 mice, predominantly upon exposure to water

integument
• longer latency to response

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
alternating hemiplegia of childhood DOID:0050635 OMIM:104290
OMIM:614820
J:262419





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory