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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-Sri)10Hhv
transgene insertion 10, Hector H Valdivia
MGI:6160741
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Ins2-rtTA)2Efr/0
Tg(tetO-Sri)10Hhv/0
involves: C57BL/6 * CBA MGI:6160822


Genotype
MGI:6160822
cx1
Allelic
Composition
Tg(Ins2-rtTA)2Efr/0
Tg(tetO-Sri)10Hhv/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-rtTA)2Efr mutation (2 available)
Tg(tetO-Sri)10Hhv mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in doxycycline-treated male mice fed a high-fat diet
• in glucose-stimulation in doxycycline-treated male mice and ex vivo islets
• in doxycycline-treated male mice fed a high-fat diet
• however, insulin sensitivity is normal

endocrine/exocrine glands
• doxycycline-treated male mice exhibit a decrease in beta to alpha cell compared with control mice
• however, mice exhibit normal mean pancreas surface, islet size, individual beta-cell or alpha-cell mass
• islet cells from doxycycline-treated male mice fed a high-fat diet exhibit improved cytosolic calcium fluxes and increased endoplasmic calcium stores

growth/size/body
N
• doxycycline-treated male mice exhibit normal weight change in response to being fed a high-fat diet





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory