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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Grntm1.1Hiok
targeted mutation 1.1, Hitoshi Okazawa
MGI:6150889
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Grntm1.1Hiok/Grn+ involves: C57BL/6J MGI:6199038


Genotype
MGI:6199038
ht1
Allelic
Composition
Grntm1.1Hiok/Grn+
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grntm1.1Hiok mutation (0 available); any Grn mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the fear-conditioning test, mice exhibit a decrease in total freezing time from 12 weeks of age
• mice treated with vemurafenib, a B-Raf inhibitor, or a PKC-alpha inhibitor, Go6976, show recovery of cognitive function in the fear-conditioning test
• in the Morris water maze test, 12 and 24 week old mice exhibit a decrease in time spent at the target region and a decrease in the number of target crossings, however latency to the platform does not differ
• mice treated with vemurafenib, a B-Raf inhibitor, or a PKC-alpha inhibitor, Go6976, show recovery of memory in the Morris water maze
• rotarod abnormalities are not detected until 24 weeks of age

growth/size/body
• brain weight is slightly lower

nervous system
• body weight is lower from birth until 16 weeks of age but recovers by 20 weeks of age
• 8 week old mice exhibit a reduction of dendritic spine density in layer 1 of frontal cortex, with an increase in spine elimination and a decrease in the abundance of stable spines over 24 hours
• treatment with vemurafenib or Go6976 rescues the reduction in the number of spines
• cytoplasmic aggregation of TDP43 from 24 weeks of age
• proportions of neurons with TDP43+ and Ub+ cytoplasmic aggregates increases over time, especially in the cerebral cortex
• mice exhibit cytoplasmic inclusion bodies from 24 weeks of age
• mice exhibit lentiform intranuclear inclusions from 24 weeks of age
• tau phosphorylation at Ser203 and mislocalization of tau to dendritic spines





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory