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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Krastm1.1Khai
targeted mutation 1.1, Kevin Haigis
MGI:6149500
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Krastm1.1Khai/Kras+
Tg(Mx1-cre)1Cgn/0 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J MGI:6505548
cn2
 		Krastm1.1Khai/Kras+
Tg(Fabp1-cre)1Jig/0 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N MGI:6505543
cn3
 		Krastm1.1Khai/Kras+
Tg(Pdx1-cre)6Tuv/0 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N MGI:6505554
cn4
 		Krastm1.1Khai/Kras+
Tg(Pdx1-cre)6Tuv/0
Trp53tm3.1Tyj/Trp53+ 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N MGI:6505559
cn5
 		Apctm2Rak/Apc+
Krastm1.1Khai/Kras+
Tg(Fabp1-cre)1Jig/0 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:6505557


Genotype
MGI:6505548
cn1
Allelic
Composition		 Krastm1.1Khai/Kras+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1.1Khai mutation (1 available); any Kras mutation (76 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:276349 )
• pIpC-induced mice die prematurely but at an older age than induced conditional Krastm4Tyj mice

hematopoietic system
abnormal hematopoietic system morphology/development ( J:276349 )
• mice induced with polyinosinic:polycytidylic acid (pIpC) develop a myelodysplastic syndrome/myeloproliferative neoplasm that is qualitatively similar to that seen in conditional Krastm4Tyj mice, but with a delayed onset
enlarged spleen ( J:276349 )
• dying pIpC-induced mice show splenomegaly
anemia ( J:276349 )
• dying pIpC-induced mice show severe anemia
decreased hemoglobin content ( J:276349 )
• hemoglobin levels decline over time in pIpC-induced mice
increased leukocyte cell number ( J:276349 )
• white blood cell counts slowly rise over time in pIpC-induced mice
increased myeloid cell number ( J:276349 )
• expansion of immature myeloid cells in the bone marrow and spleen in pIpC-induced mice
increased myeloid cell number in bone marrow ( J:276349 )
• expansion of immature myeloid cells in the bone marrow of pIpC-induced mice

immune system
enlarged spleen ( J:276349 )
• dying pIpC-induced mice show splenomegaly
increased leukocyte cell number ( J:276349 )
• white blood cell counts slowly rise over time in pIpC-induced mice

growth/size/body
enlarged spleen ( J:276349 )
• dying pIpC-induced mice show splenomegaly




Genotype
MGI:6505543
cn2
Allelic
Composition		 Krastm1.1Khai/Kras+
Tg(Fabp1-cre)1Jig/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1.1Khai mutation (1 available); any Kras mutation (76 available)
Tg(Fabp1-cre)1Jig mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal large intestine crypts of Lieberkuhn morphology ( J:276349 )
• mice show moderate colon epithelium crypt hyperplasia that is intermediate between wild-type mice and conditional Krastm4Tyj mice
abnormal colon morphology ( J:276349 )
• colons show an intermediate hyperproliferative phenotype compared to wild-type mice or conditional Krastm4Tyj mice
• Paneth cells are intact in colons

endocrine/exocrine glands
abnormal large intestine crypts of Lieberkuhn morphology ( J:276349 )
• mice show moderate colon epithelium crypt hyperplasia that is intermediate between wild-type mice and conditional Krastm4Tyj mice




Genotype
MGI:6505554
cn3
Allelic
Composition		 Krastm1.1Khai/Kras+
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1.1Khai mutation (1 available); any Kras mutation (76 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:276349 )
N
• mice do not develop intraepithelial neoplasia (PanIN) at 8 weeks, 2 months, or beyond 300 days of age
• mice treated with cerulein to induce acute pancreatitis do not develop PanIN




Genotype
MGI:6505559
cn4
Allelic
Composition		 Krastm1.1Khai/Kras+
Tg(Pdx1-cre)6Tuv/0
Trp53tm3.1Tyj/Trp53+
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1.1Khai mutation (1 available); any Kras mutation (76 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm3.1Tyj mutation (2 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:276349 )
• 9 of 12 mice develop pancreatic tumors; all cancers are invasive pancreatic ductal adenocarcinoma

mortality/aging
premature death ( J:276349 )
• median lifespan is approximately 120 days with all mice dying around 260 days, which is extended survival compared to conditional mice expressing the Krastm4Tyj allele

endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:276349 )
• 9 of 12 mice develop pancreatic tumors; all cancers are invasive pancreatic ductal adenocarcinoma

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pancreatic ductal adenocarcinoma DOID:3498 J:276349




Genotype
MGI:6505557
cn5
Allelic
Composition		 Apctm2Rak/Apc+
Krastm1.1Khai/Kras+
Tg(Fabp1-cre)1Jig/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2Rak mutation (1 available); any Apc mutation (154 available)
Krastm1.1Khai mutation (1 available); any Kras mutation (76 available)
Tg(Fabp1-cre)1Jig mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased colon adenoma incidence ( J:276349 )
• mice develop colonic tumors, characterized as adenomas with low-grade dysplasia

mortality/aging
premature death ( J:276349 )
• mice show slightly longer survival than conditional mice carrying the Krastm4Tyj allele

digestive/alimentary system
increased colon adenoma incidence ( J:276349 )
• mice develop colonic tumors, characterized as adenomas with low-grade dysplasia

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
colorectal cancer DOID:9256 OMIM:114500
 J:276349




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory