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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cabp2tm1b(KOMP)Mbp
targeted mutation 1b, Mouse Biology Program, UC Davis
MGI:6120904
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cabp2tm1b(KOMP)Mbp/Cabp2tm1b(KOMP)Mbp involves: C57BL/6N * FVB/N MGI:6155766


Genotype
MGI:6155766
hm1
Allelic
Composition
Cabp2tm1b(KOMP)Mbp/Cabp2tm1b(KOMP)Mbp
Genetic
Background
involves: C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cabp2tm1b(KOMP)Mbp mutation (0 available); any Cabp2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
N
• thresholds and amplitudes of distortion product otoacoustic emissions (DPOAEs)
• morphology of inner hair cells and their afferent synapses
• increased inactivation of voltage-gated type 1.3 Ca2+ channels in mature IHCs of cochlear apical coil in vitro at age 5 weeks, using long (500 ms) step depolarizations or trains of brief (10 ms with 5 ms interval) depolarizations
• reduced firing rates and delayed and more variable spike timing of spinal ganglion neurons (SGNs) at sound onset
• reduced amplitude of response to 80 dB click stimuli at 20 Hz rate at age P49-P63
• increased in 6-24 kHz frequency range at age P49-P63

nervous system
• increased inactivation of voltage-gated type 1.3 Ca2+ channels in mature IHCs of cochlear apical coil in vitro at age 5 weeks, using long (500 ms) step depolarizations or trains of brief (10 ms with 5 ms interval) depolarizations

mortality/aging
N
• viable

reproductive system

vision/eye
N
• intact retinal processing according to scotopic electroretinography (ERG) readings

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive nonsyndromic deafness 93 DOID:0110537 OMIM:614899
J:255028





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory