Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod6tm1(cre)Kan mutation
(0 available);
any
Neurod6 mutation
(17 available)
Plp1tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Plp1 mutation
(19 available)
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nervous system
N |
• no APP+axonal spheroids, microgliosis, astrogliosis, or increase in T-lymphocytes are seen in the hippocampal fimbria at 26 weeks of age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnptm1(cre)Kan mutation
(0 available);
any
Cnp mutation
(26 available)
Plp1tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Plp1 mutation
(19 available)
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hematopoietic system
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• density of T-lymphocytes (CD3+ cells) in the fimbria is increased at 26 weeks of age
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• microgliosis in the hippocampal fimbria at 26 weeks of age
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immune system
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• density of T-lymphocytes (CD3+ cells) in the fimbria is increased at 26 weeks of age
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• microgliosis in the hippocampal fimbria at 26 weeks of age
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nervous system
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• microgliosis in the hippocampal fimbria at 26 weeks of age
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• hippocampal fimbria exhibits APP+ axonal spheroids, microgliosis and astrogliosis, and increased density of T-lymphocytes
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• moderate, but significant, astrogliosis in the hippocampal fimbria at 26 weeks of age
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• APP+ axonal spheroids are present in the hippocampal fimbria and corpus callosum at 26 weeks of age
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