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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Plp1tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6115637
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Plp1tm1c(EUCOMM)Wtsi/Y
Neurod6tm1(cre)Kan/Neurod6+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N MGI:6160754
cn2
Plp1tm1c(EUCOMM)Wtsi/Y
Cnptm1(cre)Kan/Cnp+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N MGI:6160757


Genotype
MGI:6160754
cn1
Allelic
Composition
Plp1tm1c(EUCOMM)Wtsi/Y
Neurod6tm1(cre)Kan/Neurod6+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod6tm1(cre)Kan mutation (0 available); any Neurod6 mutation (17 available)
Plp1tm1c(EUCOMM)Wtsi mutation (0 available); any Plp1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no APP+axonal spheroids, microgliosis, astrogliosis, or increase in T-lymphocytes are seen in the hippocampal fimbria at 26 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT hereditary spastic paraplegia 2 DOID:0110773 OMIM:312920
J:245100




Genotype
MGI:6160757
cn2
Allelic
Composition
Plp1tm1c(EUCOMM)Wtsi/Y
Cnptm1(cre)Kan/Cnp+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnptm1(cre)Kan mutation (0 available); any Cnp mutation (26 available)
Plp1tm1c(EUCOMM)Wtsi mutation (0 available); any Plp1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• density of T-lymphocytes (CD3+ cells) in the fimbria is increased at 26 weeks of age
• microgliosis in the hippocampal fimbria at 26 weeks of age

immune system
• density of T-lymphocytes (CD3+ cells) in the fimbria is increased at 26 weeks of age
• microgliosis in the hippocampal fimbria at 26 weeks of age

nervous system
• microgliosis in the hippocampal fimbria at 26 weeks of age
• hippocampal fimbria exhibits APP+ axonal spheroids, microgliosis and astrogliosis, and increased density of T-lymphocytes
• moderate, but significant, astrogliosis in the hippocampal fimbria at 26 weeks of age
• APP+ axonal spheroids are present in the hippocampal fimbria and corpus callosum at 26 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hereditary spastic paraplegia 2 DOID:0110773 OMIM:312920
J:245100





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory