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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gas2l3tm1c(EUCOMM)Hmgu
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:5925364
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gas2l3tm1c(EUCOMM)Hmgu/Gas2l3tm1c(EUCOMM)Hmgu
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N MGI:6116291
cn2
Gas2l3tm1c(EUCOMM)Hmgu/Gas2l3tm1c(EUCOMM)Hmgu
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N MGI:6116294


Genotype
MGI:6116291
cn1
Allelic
Composition
Gas2l3tm1c(EUCOMM)Hmgu/Gas2l3tm1c(EUCOMM)Hmgu
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gas2l3tm1c(EUCOMM)Hmgu mutation (0 available); any Gas2l3 mutation (20 available)
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (512 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• no increase in heart weight, no dilation, and no fibrosis when tamoxifen is used to induce loss of expression in neonatal mice unlike when expression is absent in embryonic stages
• in cultured cardiomyocytes after tamoxifen induction 22% become binucleated while very few cells were binucleate before tamoxifen exposure
• increase in the proportion of cardiomyocytes with unresolved cytokinetic midbody structures indicating failed abscission

cellular
• increase in the proportion of cardiomyocytes with unresolved cytokinetic midbody structures indicating failed abscission
• increase in the proportion of cardiomyocytes with unresolved cytokinetic midbody structures indicating failed abscission

muscle
• increase in the proportion of cardiomyocytes with unresolved cytokinetic midbody structures indicating failed abscission




Genotype
MGI:6116294
cn2
Allelic
Composition
Gas2l3tm1c(EUCOMM)Hmgu/Gas2l3tm1c(EUCOMM)Hmgu
Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gas2l3tm1c(EUCOMM)Hmgu mutation (0 available); any Gas2l3 mutation (20 available)
Nkx2-5tm2(cre)Rph mutation (1 available); any Nkx2-5 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• increase in heart to body weight ratio

muscle





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory