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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-LDB3*S196L)93Mva
transgene insertion 93, Matteo Vatta
MGI:5910333
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6-LDB3*S196L)93Mva/0 involves: C57BL/6J MGI:5910334


Genotype
MGI:5910334
tg1
Allelic
Composition
Tg(Myh6-LDB3*S196L)93Mva/0
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mild focal fibrosis in ventricular myocardium at 10 months of age
• mice develop cardiac dilation at 10 months of age, but not at 4 and 7 months
• mice develop decreased fractional shortening and ejection fraction at 10 months of age
• mice exhibit left ventricular end-diastolic dilation and decreased left ventricular systolic function
• mice exhibit slower heart rate at 4 months of age
• appears as early as 4 months of age
• prolonged PR intervals in 4 month old mice
• prolonged QRS intervals in 4 month old mice
• percentage of sarcomere shortening is reduced in cardiomyocytes suggesting impaired contractile function
• the peak L-type calcium current amplitude is reduced in cardiomyocytes, the threshold and peak voltage of the I-V relationship are rightward shifted leading to reduced calcium channel function
• sodium currents are altered with cardiomyocytes showing a 10 mV rightward shift of the threshold and the peak voltage in the sodium channel I-V relationships

muscle
• mice develop decreased fractional shortening and ejection fraction at 10 months of age
• severe sarcomere derangement in the myocardium of 10 month old mice
• Z-band disorganization in the myocardium of 10 month old mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy 1C DOID:0110423 OMIM:601493
J:243711





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory