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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-Tnni3*R146G)133Rbns
transgene insertion 133, Jeffrey Robbins
MGI:5909327
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6-Tnni3*R146G)133Rbns/0 Not Specified MGI:5909329


Genotype
MGI:5909329
tg1
Allelic
Composition
Tg(Myh6-Tnni3*R146G)133Rbns/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• molecular markers of cardiac hypertrophy are activated, however no overt hypertrophy is seen

mortality/aging
• mice die between 13 and 17 days after birth

cardiovascular system
• abnormal hearts
• cardiomyocytes show short sarcomeres with wide Z bands and no visible I bands, swollen and disorganized sarcoplasmic reticulum, and abnormal mitochondrial ultrastructure and distribution
• molecular markers of cardiac hypertrophy are activated, however no overt hypertrophy is seen
• ventricles exhibit cardiomyocyte disarray, interstitial and perivascular fibrosis, and nuclear degeneration by 10 days after birth but not at E18
• however, no increase in the ventricle or body weight is seen at 10-11 days of age
• ventricles exhibit interstitial and perivascular fibrosis
• skinned papillary muscle from 10 day old mice show increased calcium sensitivity and depressed maximum tension
• however, no differences are seen in unloaded shortening velocity, maximum shortening velocity, or maximum relative power

cellular
• mitochondrial ultrastructure and distribution are abnormal in cardiomyocytes

muscle
• cardiomyocytes show short sarcomeres with wide Z bands and no visible I bands, swollen and disorganized sarcoplasmic reticulum, and abnormal mitochondrial ultrastructure and distribution
• cardiomyocytes from 9 day old mice exhibit abnormally short sarcomeres with wide Z bands and no visible I bands
• sarcomeric organization is disturbed in many areas
• cardiomyocytes from 9 day old mice lack visible I bands
• cardiomyocytes from 9 day old mice exhibit wide Z bands
• the sarcoplasmic reticulum is swollen and disorganized, with disruption of the normal spatial relationship between the sarcomeres and sarcoplasmic reticulum

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 7 DOID:0110313 OMIM:613690
J:243628





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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory