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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Wnt10atm1.1Smr
targeted mutation 1.1, Sarah E Millar
MGI:5904667
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Wnt10atm1.1Smr/Wnt10atm1.1Smr involves: 129X1/SvJ * BALB/cJ MGI:5905986


Genotype
MGI:5905986
hm1
Allelic
Composition
Wnt10atm1.1Smr/Wnt10atm1.1Smr
Genetic
Background
involves: 129X1/SvJ * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt10atm1.1Smr mutation (0 available); any Wnt10a mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• decreased alveolar bone density by 1 year age
• flattened cusps and reduced size as early as E17.5
• however, non-dental epithelia develops normally
• flattened cusps as early as E17.5
• defective root bifurcation and extension
• frequently missing molar teeth
• as early as E17.5
• half of mice develop loosely anchored ectopic molar M4 teeth
• flattened surface

integument
• defective nail growth in some mice

taste/olfaction
N
• mice exhibit normal taste response to sweet, sour, salt or bitter tastes, or for the irritant, capsaicin

behavior/neurological
• following mild, but not severe, water restriction

skeleton
• decreased alveolar bone density by 1 year age
• flattened cusps and reduced size as early as E17.5
• however, non-dental epithelia develops normally
• flattened cusps as early as E17.5
• defective root bifurcation and extension
• frequently missing molar teeth
• as early as E17.5
• half of mice develop loosely anchored ectopic molar M4 teeth

growth/size/body
• decreased alveolar bone density by 1 year age
• flattened cusps and reduced size as early as E17.5
• however, non-dental epithelia develops normally
• flattened cusps as early as E17.5
• defective root bifurcation and extension
• frequently missing molar teeth
• as early as E17.5
• half of mice develop loosely anchored ectopic molar M4 teeth
• flattened surface

digestive/alimentary system
• flattened surface

endocrine/exocrine glands





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory