All Phenotypes Mysm1<tm1b(KOMP)Wtsi> MGI Mouse

decreased pro-B cell number ( J:179287 )

• dramatic reduction in pro-B cell frequency and absolute numbers in bone marrow

arrested B cell differentiation ( J:179287 )

• in an in vitro pre-B cell colony forming assay no B cell colonies are formed from bone marrow cells

abnormal T cell differentiation ( J:179287 )

• the frequency of DN1 cells is increased and the frequency of DN2 cells is reduced; however, the frequencies of DP and DN cells are roughly equal

abnormal common lymphocyte progenitor cell morphology ( J:179287 )

• most cells in the CLP population are Ly6D^- all-lymphoid progenitors with only a few Ly6D+ B cell biased lymphoid progenitors detected

decreased hematopoietic cell number ( J:179287 )

• absolute numbers of all hematopoietic cell lineages are reduced to varying degrees

• however the frequencies of CD3+ T and CD4+ T lymphocytes, Gr1+CD11b+ myeloid cells, Ter119+ erythrocytes, and CD41+Ter119^- megakaryocytes are largely normal or elevated in various tissues

decreased B cell number ( J:179287 )

• dramatic decrease in the percentage of B220+ CD19+ B cells in the bone marrow, spleen, peripheral blood, and lymph nodes compared to littermate controls

• marked reduction the number of peripheral B cells that express surface IgM and IgD mice have only 0.25% of control B cell numbers

decreased immature B cell number ( J:179287 )

• reduction in the number and frequency of pre-pro-B cells in the bone marrow

decreased pre-B cell number ( J:179287 )

• dramatic reduction in pre-B cell frequency and absolute numbers in bone marrow

pancytopenia ( J:179287 )

postnatal growth retardation ( J:179287 )

short tail ( J:179287 )

• truncated tail