All Phenotypes Slc13a4<tm1d(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc13a4^{tm1d(EUCOMM)Wtsi}
targeted mutation 1d, Wellcome Trust Sanger Institute
MGI:5881938

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc13a4^{tm1d(EUCOMM)Wtsi}/Slc13a4^{tm1d(EUCOMM)Wtsi}	involves: C57BL/6 * CBA	MGI:5896627
cn2	Slc13a4^{tm1c(EUCOMM)Wtsi}/Slc13a4^{tm1d(EUCOMM)Wtsi} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: C57BL/6 * CBA	MGI:5896626

Allelic Composition	Slc13a4^{tm1d(EUCOMM)Wtsi}/Slc13a4^{tm1d(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc13a4^{tm1d(EUCOMM)Wtsi} mutation (0 available); any Slc13a4 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:239786 )

• all are dead by E18.5, phenocoping mice homozygous for Slc13a4 ^{tm1a(EUCOMM)Wtsi}

Allelic Composition	Slc13a4^{tm1c(EUCOMM)Wtsi}/Slc13a4^{tm1d(EUCOMM)Wtsi} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (42 available)
Slc13a4^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Slc13a4 mutation (34 available)
Slc13a4^{tm1d(EUCOMM)Wtsi} mutation (0 available); any Slc13a4 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:239786 )

N	• with paternal inheritance of the cre transgene mice are viable

lethality throughout fetal growth and development, complete penetrance ( J:239786 )

• with maternal inheritance of the cre transgene these mice phenocopy mice homozygous for Slc13a4 ^{tm1a(EUCOMM)Wtsi}

embryo

embryo phenotype ( J:239786 )

N	• with paternal inheritance of the cre transgene restricting cre expression to the embryo and not the extraembryonic tissues, placental transport of sulfate is similar to controls and embryos resemble controls

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