Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col5a2tm1.2Dgr mutation
(0 available);
any
Col5a2 mutation
(65 available)
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mortality/aging
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• lack of heart beat in some embryos at E11.5 and death at E12 to E12.5
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integument
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• collagen fibrils have diameters about 50% larger than wild-type fibrils
• however, E10.5 embryos have similar numbers of collagen fibrils as wild-type embryos
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• embryos develop pallor at E11.5
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cardiovascular system
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• embryos show congestion of blood and an absence of clearly visible vasculature at E11.5
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Allelic
Composition |
Col5a2tm1.2Dgr/Col5a2+
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Genetic
Background |
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col5a2tm1.2Dgr mutation
(0 available);
any
Col5a2 mutation
(65 available)
|
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cardiovascular system
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• 51% reduction of tensile strength (breaking strength) and a 59% reduction of elastic modulus (stiffness) of the ascending aortas
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integument
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• some collagen fibrils show irregular contours and a slight increase in fibril diameter in P50 skin with irregular fibril contour, but not increased fibril diameter, persisting at 15 weeks
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• skin exhibits increased extensibility at high strain, but not low strain, at 15 weeks of age indicating reduced skin stiffness
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• tensile strength of skin is reduced about 48% compared to wild-type skin
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Analysis Tools