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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rai1tm2.1Luo
targeted mutation 2.1, Liqun Luo
MGI:5816464
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Emx1tm1(cre)Krj/?
Rai1tm2.1Luo/Rai1tm2.1Luo
either: (involves: 129S1/Sv * 129S2/SvPas * C57BL/6) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6) MGI:5817664
cn2
Gad2tm2(cre)Zjh/?
Rai1tm2.1Luo/Rai1tm2.1Luo
either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6) MGI:5817645
cn3
Rai1tm2.1Luo/Rai1tm2.1Luo
Slc17a6tm2(cre)Lowl/?
either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6) MGI:5817637
cn4
Rai1tm2.1Luo/Rai1+
Slc17a6tm2(cre)Lowl/?
either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6) MGI:5817641
cn5
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Gfap-cre)73.12Mvs/?
either: (involves: 129S1/Sv * BALB/c * C57BL/6 * C57BL/6NHsd) or (involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NHsd) MGI:5817666
cn6
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Sim1-cre)1Lowl/?
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB) MGI:5817650
cn7
Rai1tm2.1Luo/Rai1+
Tg(Sim1-cre)1Lowl/?
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB) MGI:5817653
cn8
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Nr5a1-cre)7Lowl/?
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB) MGI:5817657
cn9
Rai1tm2.1Luo/Rai1+
Tg(Nr5a1-cre)7Lowl/?
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB) MGI:5817661
cn10
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Nes-cre)1Kln/?
either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL) MGI:5817471
cn11
Rai1tm2.1Luo/Rai1+
Tg(Nes-cre)1Kln/?
either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL) MGI:5817609
cn12
Rai1tm2.2Luo/Rai1tm2.1Luo
Tg(Nes-cre)1Kln/?
either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL) MGI:5817614


Genotype
MGI:5817664
cn1
Allelic
Composition
Emx1tm1(cre)Krj/?
Rai1tm2.1Luo/Rai1tm2.1Luo
Genetic
Background
either: (involves: 129S1/Sv * 129S2/SvPas * C57BL/6) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (27 available)
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice do not exhibit differences in behavior, motor function or body weight from controls




Genotype
MGI:5817645
cn2
Allelic
Composition
Gad2tm2(cre)Zjh/?
Rai1tm2.1Luo/Rai1tm2.1Luo
Genetic
Background
either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad2tm2(cre)Zjh mutation (3 available); any Gad2 mutation (16 available)
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• decreased freezing behavior in contextual memory recall
• decreased freezing behavior in cued recall




Genotype
MGI:5817637
cn3
Allelic
Composition
Rai1tm2.1Luo/Rai1tm2.1Luo
Slc17a6tm2(cre)Lowl/?
Genetic
Background
either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (59 available)
Slc17a6tm2(cre)Lowl mutation (2 available); any Slc17a6 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• decreased freezing behavior in contextual recall in trace fear-conditioning task
• decreased freezing behavior in cued recall
• increased time required to descend in pole test
• increased latency to fall in wire hang test

growth/size/body
• males and females become obese at 9 and 7 weeks, respectively and are 56% (males) and 116% (females) heavier than controls at 20 weeks




Genotype
MGI:5817641
cn4
Allelic
Composition
Rai1tm2.1Luo/Rai1+
Slc17a6tm2(cre)Lowl/?
Genetic
Background
either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (59 available)
Slc17a6tm2(cre)Lowl mutation (2 available); any Slc17a6 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• increased latency to fall in wire hang test

growth/size/body
• males and females exhibit 16% and 29% (respectively ) increased body weight as compared to controls




Genotype
MGI:5817666
cn5
Allelic
Composition
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Gfap-cre)73.12Mvs/?
Genetic
Background
either: (involves: 129S1/Sv * BALB/c * C57BL/6 * C57BL/6NHsd) or (involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NHsd)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (59 available)
Tg(Gfap-cre)73.12Mvs mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice do not exhibit differences in behavior, motor function or body weight




Genotype
MGI:5817650
cn6
Allelic
Composition
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Sim1-cre)1Lowl/?
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (59 available)
Tg(Sim1-cre)1Lowl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• increased fat pad weight: gonadal, subcutaneous, retroperitoneal, mesenteric and BAT

behavior/neurological
N
• males exhibit no motor weakness in wire hang test
• hyperphagic with a 47% increase in average daily food intake
• decreased horizontal locomotor activity

growth/size/body
• mice are 57% heavier than controls at 20 weeks of age

homeostasis/metabolism




Genotype
MGI:5817653
cn7
Allelic
Composition
Rai1tm2.1Luo/Rai1+
Tg(Sim1-cre)1Lowl/?
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (59 available)
Tg(Sim1-cre)1Lowl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• females are 12.7% heavier than controls at 20 weeks of age




Genotype
MGI:5817657
cn8
Allelic
Composition
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Nr5a1-cre)7Lowl/?
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (59 available)
Tg(Nr5a1-cre)7Lowl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• males exhibit no motor weakness in wire hang test

growth/size/body
• females are 27% heavier than controls at 20 weeks of age




Genotype
MGI:5817661
cn9
Allelic
Composition
Rai1tm2.1Luo/Rai1+
Tg(Nr5a1-cre)7Lowl/?
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (59 available)
Tg(Nr5a1-cre)7Lowl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• females are 27% heavier than controls at 20 weeks of age




Genotype
MGI:5817471
cn10
Allelic
Composition
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Nes-cre)1Kln/?
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (59 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• males perform similar to controls in assays for gait, velocity, vertical activity, anxiety, sociability and cognition
• males have normal hearing and pain responses
• decreased freezing behavior after repeated tone-shock pairings during training
• decreased freezing behavior in contextual recall in trace fear-conditioning task
• decreased freezing behavior in cued recall
• reduced tendency to explore new arm in Y maze
• hindlimb clasping
• in pole test males slip from pole or climb down in a slow and uncoordinated fashion
• decreased latency to fall in wire hang test

growth/size/body
• female mice become overweight beginning at 5 weeks of age
• at 20 weeks female mice are 101% heavier than controls
• mice are smaller than littermates prior to weaning

mortality/aging
• more than 80% of mice die before 25 weeks of age

skeleton
• kyphosis in 10% of mice that die before 10 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Smith-Magenis syndrome DOID:0060768 OMIM:182290
J:237687




Genotype
MGI:5817609
cn11
Allelic
Composition
Rai1tm2.1Luo/Rai1+
Tg(Nes-cre)1Kln/?
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (59 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• males exhibit a decreased latency to fall in wire hang test

growth/size/body
• female mice become overweight beginning at 7 weeks of age
• at 20 weeks female mice are 35% heavier than controls




Genotype
MGI:5817614
cn12
Allelic
Composition
Rai1tm2.2Luo/Rai1tm2.1Luo
Tg(Nes-cre)1Kln/?
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (59 available)
Rai1tm2.2Luo mutation (0 available); any Rai1 mutation (59 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• female mice become overweight beginning at 7 weeks of age





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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory