All Phenotypes Rai1<tm2.1Luo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rai1^tm2.1Luo
targeted mutation 2.1, Liqun Luo
MGI:5816464

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Emx1^tm1(cre)Krj/? Rai1^tm2.1Luo/Rai1^tm2.1Luo	either: (involves: 129S1/Sv * 129S2/SvPas * C57BL/6) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6)	MGI:5817664
cn2	Gad2^tm2(cre)Zjh/? Rai1^tm2.1Luo/Rai1^tm2.1Luo	either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6)	MGI:5817645
cn3	Rai1^tm2.1Luo/Rai1^tm2.1Luo Slc17a6^tm2(cre)Lowl/?	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)	MGI:5817637
cn4	Rai1^tm2.1Luo/Rai1⁺ Slc17a6^tm2(cre)Lowl/?	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)	MGI:5817641
cn5	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Gfap-cre)73.12Mvs/?	either: (involves: 129S1/Sv * BALB/c * C57BL/6 * C57BL/6NHsd) or (involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NHsd)	MGI:5817666
cn6	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Nr5a1-cre)7Lowl/?	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)	MGI:5817657
cn7	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Sim1-cre)1Lowl/?	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)	MGI:5817650
cn8	Rai1^tm2.1Luo/Rai1⁺ Tg(Sim1-cre)1Lowl/?	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)	MGI:5817653
cn9	Rai1^tm2.1Luo/Rai1⁺ Tg(Nr5a1-cre)7Lowl/?	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)	MGI:5817661
cn10	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Nes-cre)1Kln/?	either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)	MGI:5817471
cn11	Rai1^tm2.1Luo/Rai1⁺ Tg(Nes-cre)1Kln/?	either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)	MGI:5817609
cn12	Rai1^tm2.2Luo/Rai1^tm2.1Luo Tg(Nes-cre)1Kln/?	either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)	MGI:5817614

Allelic Composition	Emx1^tm1(cre)Krj/? Rai1^tm2.1Luo/Rai1^tm2.1Luo
Genetic Background	either: (involves: 129S1/Sv * 129S2/SvPas * C57BL/6) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:237687 )

• mice do not exhibit differences in behavior, motor function or body weight from controls

Allelic Composition	Gad2^tm2(cre)Zjh/? Rai1^tm2.1Luo/Rai1^tm2.1Luo
Genetic Background	either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad2^tm2(cre)Zjh mutation (3 available); any Gad2 mutation (60 available)
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal associative learning ( J:237687 )

impaired contextual conditioning behavior ( J:237687 )

• decreased freezing behavior in contextual memory recall

impaired cued conditioning behavior ( J:237687 )

• decreased freezing behavior in cued recall

Allelic Composition	Rai1^tm2.1Luo/Rai1^tm2.1Luo Slc17a6^tm2(cre)Lowl/?
Genetic Background	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Slc17a6^tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal associative learning ( J:237687 )

impaired contextual conditioning behavior ( J:237687 )

• decreased freezing behavior in contextual recall in trace fear-conditioning task

impaired cued conditioning behavior ( J:237687 )

• decreased freezing behavior in cued recall

impaired coordination ( J:237687 )

• increased time required to descend in pole test

• increased latency to fall in wire hang test

growth/size/body

obese ( J:237687 )

• males and females become obese at 9 and 7 weeks, respectively and are 56% (males) and 116% (females) heavier than controls at 20 weeks

Allelic Composition	Rai1^tm2.1Luo/Rai1⁺ Slc17a6^tm2(cre)Lowl/?
Genetic Background	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:237687 )

• increased latency to fall in wire hang test

growth/size/body

increased body weight ( J:237687 )

• males and females exhibit 16% and 29% (respectively ) increased body weight as compared to controls

Allelic Composition	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Gfap-cre)73.12Mvs/?
Genetic Background	either: (involves: 129S1/Sv * BALB/c * C57BL/6 * C57BL/6NHsd) or (involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NHsd)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Gfap-cre)73.12Mvs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:237687 )

• mice do not exhibit differences in behavior, motor function or body weight

Allelic Composition	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Nr5a1-cre)7Lowl/?
Genetic Background	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Nr5a1-cre)7Lowl mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:237687 )

N	• males exhibit no motor weakness in wire hang test

growth/size/body

increased body weight ( J:237687 )

• females are 27% heavier than controls at 20 weeks of age

Allelic Composition	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Sim1-cre)1Lowl/?
Genetic Background	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Sim1-cre)1Lowl mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased body fat mass ( J:237687 )

increased total fat pad weight ( J:237687 )

• increased fat pad weight: gonadal, subcutaneous, retroperitoneal, mesenteric and BAT

behavior/neurological

behavior/neurological phenotype ( J:237687 )

N	• males exhibit no motor weakness in wire hang test

polyphagia ( J:237687 )

• hyperphagic with a 47% increase in average daily food intake

decreased locomotor activity ( J:237687 )

• decreased horizontal locomotor activity

growth/size/body

increased body fat mass ( J:237687 )

increased lean body mass ( J:237687 )

obese ( J:237687 )

• mice are 57% heavier than controls at 20 weeks of age

homeostasis/metabolism

increased cholesterol level ( J:237687 )

increased circulating HDL cholesterol level ( J:237687 )

increased circulating LDL cholesterol level ( J:237687 )

increased circulating VLDL cholesterol level ( J:237687 )

increased triglyceride level ( J:237687 )

Allelic Composition	Rai1^tm2.1Luo/Rai1⁺ Tg(Sim1-cre)1Lowl/?
Genetic Background	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Sim1-cre)1Lowl mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:237687 )

• females are 12.7% heavier than controls at 20 weeks of age

Allelic Composition	Rai1^tm2.1Luo/Rai1⁺ Tg(Nr5a1-cre)7Lowl/?
Genetic Background	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Nr5a1-cre)7Lowl mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:237687 )

• females are 27% heavier than controls at 20 weeks of age

Allelic Composition	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Nes-cre)1Kln/?
Genetic Background	either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:237687 )

N	• males perform similar to controls in assays for gait, velocity, vertical activity, anxiety, sociability and cognition • males have normal hearing and pain responses

abnormal associative learning ( J:237687 )

• decreased freezing behavior after repeated tone-shock pairings during training

impaired contextual conditioning behavior ( J:237687 )

• decreased freezing behavior in contextual recall in trace fear-conditioning task

impaired cued conditioning behavior ( J:237687 )

• decreased freezing behavior in cued recall

abnormal spatial working memory ( J:237687 )

• reduced tendency to explore new arm in Y maze

limb grasping ( J:237687 )

• hindlimb clasping

impaired coordination ( J:237687 )

• in pole test males slip from pole or climb down in a slow and uncoordinated fashion

• decreased latency to fall in wire hang test

growth/size/body

obese ( J:237687 )

• female mice become overweight beginning at 5 weeks of age

• at 20 weeks female mice are 101% heavier than controls

decreased body size ( J:237687 )

• mice are smaller than littermates prior to weaning

mortality/aging

premature death ( J:237687 )

• more than 80% of mice die before 25 weeks of age

skeleton

kyphosis ( J:237687 )

• kyphosis in 10% of mice that die before 10 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Smith-Magenis syndrome		DOID:0060768	OMIM:182290	J:237687

Allelic Composition	Rai1^tm2.1Luo/Rai1⁺ Tg(Nes-cre)1Kln/?
Genetic Background	either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:237687 )

• males exhibit a decreased latency to fall in wire hang test

growth/size/body

obese ( J:237687 )

• female mice become overweight beginning at 7 weeks of age

• at 20 weeks female mice are 35% heavier than controls

Allelic Composition	Rai1^tm2.2Luo/Rai1^tm2.1Luo Tg(Nes-cre)1Kln/?
Genetic Background	either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Rai1^tm2.2Luo mutation (0 available); any Rai1 mutation (73 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

obese ( J:237687 )

• female mice become overweight beginning at 7 weeks of age

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