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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-MYC,-OVAL)#Gtgm
transgene insertion, Ines Guetgemann
MGI:5811153
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Cebpb-tTA)5Bjd/0
Tg(tetO-MYC,-OVAL)#Gtgm/0
B6J.Cg-Tg(Cebpb-tTA)5Bjd Tg(tetO-MYC,-OVAL)#Gtgm MGI:6197223


Genotype
MGI:6197223
cx1
Allelic
Composition
Tg(Cebpb-tTA)5Bjd/0
Tg(tetO-MYC,-OVAL)#Gtgm/0
Genetic
Background
B6J.Cg-Tg(Cebpb-tTA)5Bjd Tg(tetO-MYC,-OVAL)#Gtgm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cebpb-tTA)5Bjd mutation (3 available)
Tg(tetO-MYC,-OVAL)#Gtgm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice become moribund with multifocal hepatocellular carcinoma within 5-8 weeks when doxycycline is removed at birth

neoplasm
• mice develop multifocal hepatocellular carcinoma within 5-8 weeks of birth, with initial tumor foci as early as 4 weeks after induction with the removal of doxycline

immune system
• CD8+ T cells from Tg(TcraTcrb)1100Mjb expressing mice transferred into these mice are hyporesponsive and fail to become cytotoxic effect cells indicating cytotoxic T lymphocyte tolerance induction

liver/biliary system
• mice develop multifocal hepatocellular carcinoma within 5-8 weeks of birth, with initial tumor foci as early as 4 weeks after induction with the removal of doxycline

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:186226





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory