All Phenotypes Mir196a-2<tm1.1Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mir196a-2^tm1.1Wtsi
targeted mutation 1.1, Wellcome Trust Sanger Institute
MGI:5805881

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir196a-2^tm1.1Wtsi/Mir196a-2^tm1.1Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5805942
cx2	Mir196a-2^tm1.1Wtsi/Mir196a-2^tm1.1Wtsi Mir196b^tm1.1Wtsi/Mir196b^tm1.1Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5805944
cx3	Mir196a-1^tm1.1Wtsi/Mir196a-1^tm1.1Wtsi Mir196a-2^tm1.1Wtsi/Mir196a-2^tm1.1Wtsi Mir196b^tm1.1Wtsi/Mir196b^tm1.1Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5805945

Allelic Composition	Mir196a-2^tm1.1Wtsi/Mir196a-2^tm1.1Wtsi
Genetic Background	involves: C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir196a-2^tm1.1Wtsi mutation (0 available); any Mir196a-2 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal sacrum morphology ( J:226712 )

• posterior displacement of the sacrum

lumbar vertebral transformation ( J:226712 )

• the first lumbar vertebra has a rudimentary rib nubbin indicating an anterior homeotic transformation

• one-quarter of mice exhibit anterior homeotic transformation of all lumbar vertebrae

sacral vertebral transformation ( J:226712 )

• one-quarter of mice exhibit anterior homeotic transformation of all sacral elements with posterior displacement of the sacrum

Allelic Composition	Mir196a-2^tm1.1Wtsi/Mir196a-2^tm1.1Wtsi Mir196b^tm1.1Wtsi/Mir196b^tm1.1Wtsi
Genetic Background	involves: C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir196a-2^tm1.1Wtsi mutation (0 available); any Mir196a-2 mutation (2 available)
Mir196b^tm1.1Wtsi mutation (0 available); any Mir196b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased rib number ( J:226712 )

• 2 pairs of supernumerary ribs

vertebral transformation ( J:226712 )

• fully penetrant anterior homeotic transformation of all subsequent elements following supernumerary ribs

Allelic Composition	Mir196a-1^tm1.1Wtsi/Mir196a-1^tm1.1Wtsi Mir196a-2^tm1.1Wtsi/Mir196a-2^tm1.1Wtsi Mir196b^tm1.1Wtsi/Mir196b^tm1.1Wtsi
Genetic Background	involves: C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir196a-1^tm1.1Wtsi mutation (0 available); any Mir196a-1 mutation (5 available)
Mir196a-2^tm1.1Wtsi mutation (0 available); any Mir196a-2 mutation (2 available)
Mir196b^tm1.1Wtsi mutation (0 available); any Mir196b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased rib number ( J:226712 )

• 2 pairs of supernumerary ribs as in Mir196a-2 and Mir196b double homozygote nulls

vertebral transformation ( J:226712 )

• fully penetrant anterior homeotic transformation of all subsequent elements following supernumerary ribs as in Mir196a-2 and Mir196b double homozygote nulls

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