All Phenotypes Adam7<tm1Tigm> MGI Mouse

reproductive system phenotype ( J:226260 )

N	• female mice exhibit normal fertility • male mice exhibit normal testis to body weight and epididymis to body weight ratios

kinked sperm flagellum ( J:226260 )

• uterine sperm exhibit abnormal tails with repeated bending resulting in an angulated, zigzag pattern

abnormal sperm motility ( J:226260 )

• reduced motility in vitro

abnormal epididymis morphology ( J:226260 )

• increased circumference of the lumina

spermatic granuloma ( J:226260 )

• in caput epididymis

abnormal caput epididymis morphology ( J:226260 )

• sperm granulomas and mineralization-like features

abnormal cauda epididymis morphology ( J:226260 )

• hyperplasia and vacuolation

abnormal epididymis epithelium morphology ( J:226260 )

• cell height is dramatically reduced in segment I/segment II and modestly reduced in segment III in the caput regions

• however, mice exhibit normal cell numbers in the caput epithelium and normal epithelial cell height and luminal diameter in the corpus or cauda epididymides

reduced male fertility ( J:226260 )

impaired fertilization ( J:226260 )

• male sperm fertilize fewer wild-type eggs than wild-type sperm

• sperm fail to fully disperse cumulus-oocyte complexes in vitro