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Allele Symbol Allele Name Allele ID |
Tg(Mafg-Nfe2l1)1Mym transgene insertion 1, Masayuki Yamamoto MGI:5804114 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lower body weight when fed a normal diet
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| N |
• Background Sensitivity: mice on the congenic C57BL/6J background do not exhibit increased blood glucose levels as seen on a mixed background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lower body weight than wild-type mice by 7 weeks of age when fed a regular diet
• mice fed a high-fat diet beginning at 6 weeks of age exhibit a lower body weight than high-fat diet fed wild-type mice
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• increase is liver tissue weight in mice fed a normal diet which is further enhanced on a high-fat diet
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• plasma beta-hydroxybutyrate levels of high fat diet fed mice is higher than in wild-type mice
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• plasma ammonia levels are decreased in both normal diet and high fat diet fed mice
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• the liver of high-fat diet fed mice exhibits increased pyruvate, acetyl coenzyme A, citrate, and isocitrate levels and decreased lactate levels
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• blood glucose level is increased in mice fed a normal diet
• mice fed a high-fat diet exhibit highly increased blood glucose levels compared to wild-type mice fed the same diet which show a mild increase in blood glucose levels
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• plasma insulin level is increased in mice fed a normal diet
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• both normal diet and high-fat diet fed mice show higher blood glucose levels after insulin injection compared to wild-type mice, indicating insulin resistance
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• mice fed a high-fat diet develop diabetes mellitus
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• the insulin-positive area in pancreatic sections is increased, suggesting constitutively activated insulin secretion
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• islets are larger in mice fed a regular diet
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• increase is liver tissue weight in mice fed a normal diet which is further enhanced on a high-fat diet
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| type 2 diabetes mellitus | DOID:9352 |
OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 |
J:230118 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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