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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dnm1tm1.2Frk
targeted mutation 1.2, Wayne N Frankel
MGI:5800540
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dnm1tm1.2Frk/Dnm1tm1.2Frk B6.129(Cg)-Dnm1tm1.2Frk MGI:5800563
ht2
Dnm1Ftfl/Dnm1tm1.2Frk involves: 129 * C57BL/6J * FVB MGI:5800565


Genotype
MGI:5800563
hm1
Allelic
Composition
Dnm1tm1.2Frk/Dnm1tm1.2Frk
Genetic
Background
B6.129(Cg)-Dnm1tm1.2Frk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1tm1.2Frk mutation (0 available); any Dnm1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice do not display spontaneous seizures and exhibit a normal electroconvulsive threshold




Genotype
MGI:5800565
ht2
Allelic
Composition
Dnm1Ftfl/Dnm1tm1.2Frk
Genetic
Background
involves: 129 * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1Ftfl mutation (2 available); any Dnm1 mutation (22 available)
Dnm1tm1.2Frk mutation (0 available); any Dnm1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• due to lethal seizures

nervous system
• lethal maximal seizures with earlier onset (6 to 7 weeks) and increased severity compared with with Dnm1Ftfl heterozygotes (11 to 12 weeks)
• reduced electroconvulsive threshold compared with Dnm1Ftfl heterozygotes
• abnormal interictal EEG patterns with episodes of epileptiform spikes

behavior/neurological
• lethal maximal seizures with earlier onset (6 to 7 weeks) and increased severity compared with with Dnm1Ftfl heterozygotes (11 to 12 weeks)
• reduced electroconvulsive threshold compared with Dnm1Ftfl heterozygotes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
idiopathic generalized epilepsy DOID:1827 OMIM:600669
J:235711





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory