Phenotypes associated with this allele

• Allele Symbol: Cd82^tm1.1Xaz
• Allele Name: targeted mutation 1.1, Xin A Zhang
• Allele ID: MGI:5790985
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd82^tm1.1Xaz/Cd82^tm1.1Xaz	B6NCr.Cg-Cd82^tm1.1Xaz	MGI:5791908

Genotype
MGI:5791908

hm1

• Allelic Composition: Cd82^tm1.1Xaz/Cd82^tm1.1Xaz
• Genetic Background: B6NCr.Cg-Cd82^tm1.1Xaz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal induced retina neovascularization ( J:234155 )

• high number and area of tuft formation following hypoxia and return to normoxia

abnormal tumor vascularization ( J:234155 )

• increased in implanted tumors

increased angiogenesis ( J:234155 )

• in a Matrigel plug angiogenesis assay with increased vascular area and microvessel density

• after 1 week in response to myocardial infarction

• ex vivo, aortic rings exhibit increased microvascular sprouting with increased length and area of sprouted vessels compared with wild-type mice

• however, lumen formation is proportional to more vasculature and retinal angiogenesis is normal

abnormal vascular endothelial cell migration ( J:234155 )

• increased migration toward chemoattractants, invasion into Matrigel and in vivo and increased penetration distance of endothelial cells from their coated beads in fibrin gel

abnormal response to cardiac infarction ( J:234155 )

• 1 week after myocardial infarction, mice exhibit increased angiogenesis compared with wild-type mice

cellular

abnormal vascular endothelial cell migration ( J:234155 )

• increased migration toward chemoattractants, invasion into Matrigel and in vivo and increased penetration distance of endothelial cells from their coated beads in fibrin gel

homeostasis/metabolism

abnormal response to cardiac infarction ( J:234155 )

• 1 week after myocardial infarction, mice exhibit increased angiogenesis compared with wild-type mice

neoplasm

abnormal tumor vascularization ( J:234155 )

• increased in implanted tumors

vision/eye

abnormal induced retina neovascularization ( J:234155 )

• high number and area of tuft formation following hypoxia and return to normoxia