Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm1.1Irt mutation
(1 available);
any
Ddit3 mutation
(20 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation
(6 available);
any
Speer6-ps1 mutation
(4 available)
Tg(Mup3-Plau)350-2Eps mutation
(0 available)
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liver/biliary system
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• mice fed a high fat diet develop hepatocellular carcinoma and show increased tumor multiplicity without affecting tumor size compared to single Tg(Mup3-Plau)350-2Eps transgenic mice
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neoplasm
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• mice fed a high fat diet develop hepatocellular carcinoma and show increased tumor multiplicity without affecting tumor size compared to single Tg(Mup3-Plau)350-2Eps transgenic mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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homeostasis/metabolism
liver/biliary system
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• livers become slightly pale between 3 and 4 week of age
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• mice develop diffuse lesions in the livers by 1 month of age
• multiple small red foci become visible on the surface of the liver between 4 and 5 weeks of age
• by 8 weeks of age, livers are entirely red but have a rough, nodular surface
• older mice develop hepatic neoplasms
• hepatic tumors show a latency of 9 to 26 months
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neoplasm
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• mice develop diffuse lesions in the livers by 1 month of age
• multiple small red foci become visible on the surface of the liver between 4 and 5 weeks of age
• by 8 weeks of age, livers are entirely red but have a rough, nodular surface
• older mice develop hepatic neoplasms
• hepatic tumors show a latency of 9 to 26 months
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cardiovascular system
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• mice do not exhibit perinatal hemorrhage
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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homeostasis/metabolism
integument
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• some mice display subcutaneous edema
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cellular
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• high fat diet fed mice show distended and dilated endoplasmic reticulum
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• livers of high fat diet fed mice exhibit continuous hepatocyte death and compensatory proliferation
• hepatocytes treated with PA show more extensive lipotoxic cell death than wild-type hepatocytes
• PA treated hepatocytes treated with the chemical chaperons 4-phenylbutyrate (4-PBA) and tauro-ursodeoxycholic acid (TUDCA), which reduce ER stress, show a more pronounced attenuation of cell death than wild-type hepatocytes
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• livers of high fat diet fed mice show increased apoptotic and necrotic cell death
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homeostasis/metabolism
immune system
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• high fat diet fed mice show increased levels of IL-1beta in the liver at 24 weeks of age
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• high fat diet fed mice show increased levels of TNF in the liver at 24 weeks of age
• TUDCA treatment of high fat diet fed mice inhibits the TNF increase seen in the liver
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• mice fed a high fat diet exhibit extensive immune infiltration into the liver and numerous ballooning hepatocytes, indicating non-alcoholic steatohepatitis
• mice fed a high fat diet show an increase in the number of F4/80-positive macrophages in the liver
• TUDCA treatment of high fat diet fed mice inhibits the increase in macrophage infiltration in the liver
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liver/biliary system
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• livers of high fat diet fed mice exhibit continuous hepatocyte death and compensatory proliferation
• hepatocytes treated with PA show more extensive lipotoxic cell death than wild-type hepatocytes
• PA treated hepatocytes treated with the chemical chaperons 4-phenylbutyrate (4-PBA) and tauro-ursodeoxycholic acid (TUDCA), which reduce ER stress, show a more pronounced attenuation of cell death than wild-type hepatocytes
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• livers of high fat diet fed mice show increased apoptotic and necrotic cell death
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• 30% of normal chow fed mice display a few tiny nodules in the liver at 40 weeks of age, indicating hyperplasia
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• mice fed a high fat diet exhibit elevated liver cholesterol levels
• high fat diet fed mice treated with TUDCA at 16 weeks of age exhibit reduced hepatic cholesterol levels
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• mice fed a standard chow diet show an increase in C16:0 palmitic acid and longer chain fatty acid in the liver compared to wild-type mice, which is further enhanced by high fat diet feeding
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• mice fed a high fat diet exhibit elevated liver triglycerides
• high fat diet fed mice treated with TUDCA at 16 weeks of age exhibit hepatic triglyceride levels
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• mice fed a high fat diet exhibit extensive immune infiltration into the liver and numerous ballooning hepatocytes, indicating non-alcoholic steatohepatitis
• mice fed a high fat diet show an increase in the number of F4/80-positive macrophages in the liver
• TUDCA treatment of high fat diet fed mice inhibits the increase in macrophage infiltration in the liver
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• mice fed normal chow exhibit hepatocyte damage at 5 weeks of age but this disappears at 24 weeks, except for mild inflammation and spotty necrosis
• mice fed a high fat diet exhibit numerous ballooning hepatocytes
• high fat diet fed mice treated with TUDCA at 16 weeks of age exhibit attenuation of hepatocyte ballooning
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• mice fed a standard chow diet exhibit mild spontaneous lipid accumulation in the liver at 5 weeks of age that is diminished by 16 weeks of age
• mice fed a high fat diet show extensive lipid accumulation in the liver
• high fat diet fed mice treated with TUDCA at 16 weeks of age exhibit attenuation of hepatosteatosis
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• mice fed a high fat diet show pericelluar and bridging fibrosis in the liver
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• high fat diet fed mice develop small tumors on the liver surface by 32 weeks of age and large tumors at 40 weeks
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• 30% of tumors larger than 2 mm are hepatocellular carcinomas, similar to human steatohepatitic hepatocellular carcinomas, although some show a classical thick trabecular pattern
• hepatocellular carcinoma progenitor cell-transplanted mutants develop multiple hepatocellular carcinoma nodules after 5 months
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• 70% of tumors are either typical or steatohepatic adenomas
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neoplasm
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• high fat diet fed mice develop small tumors on the liver surface by 32 weeks of age and large tumors at 40 weeks
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• 30% of tumors larger than 2 mm are hepatocellular carcinomas, similar to human steatohepatitic hepatocellular carcinomas, although some show a classical thick trabecular pattern
• hepatocellular carcinoma progenitor cell-transplanted mutants develop multiple hepatocellular carcinoma nodules after 5 months
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• 70% of tumors are either typical or steatohepatic adenomas
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growth/size/body
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• 30% of normal chow fed mice display a few tiny nodules in the liver at 40 weeks of age, indicating hyperplasia
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