All Phenotypes Bmpr2<tm1Mmue> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmpr2^tm1Mmue/Bmpr2^tm1Mmue	B6.129S1-Bmpr2^tm1Mmue	MGI:5827836
ht2	Bmpr2^tm1Mmue/Bmpr2⁺	B6.129S1-Bmpr2^tm1Mmue	MGI:5827840
cx3	Bmpr2^tm1Mmue/Bmpr2⁺ Smad1^tm1Rjle/Smad1⁺	involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6	MGI:5827848

Allelic Composition	Bmpr2^tm1Mmue/Bmpr2^tm1Mmue
Genetic Background	B6.129S1-Bmpr2^tm1Mmue

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2^tm1Mmue mutation (0 available); any Bmpr2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality, complete penetrance ( J:224752 )

• mice are nonviable

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal pulmonary artery morphology ( J:224752 )

• 6 month old mice exhibit enhanced muscularization of peripheral pulmonary arteries in the lung

increased right ventricle systolic pressure ( J:224752 )

• mice exhibit normal right ventricular systolic pressure at 3 months of age but develop elevated right ventricular systolic pressure by 6 months of age

• however, mice do not exhibit right ventricular hypertrophy and show no differences in left ventricular end diastolic pressure or cardiac output at 6 months

pulmonary hypertension ( J:224752 )

• mice exhibit pulmonary arterial hypertension by 6 months of age

• treatment of 6 month old mice with daily intraperitoneal injection of BMP9 for 4 weeks reverses all indices of pulmonary arterial hypertension, returning right ventricular systolic pressure to normal and reversing the enhanced pulmonary arterial muscularization

increased vascular permeability ( J:224752 )

• monolayers of pulmonary endothelial cells in vitro show increased permeability at baseline and following LPS stimulation

• mice injected with LPS develop increased pulmonary vascular leak compared to wild-type mice

• treatment with BMP9 prevents vascular leak to a similar degree as in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary pulmonary hypertension		DOID:14557	OMIM:178600 OMIM:265400 OMIM:615342 OMIM:615343 OMIM:615344	J:224752

Allelic Composition	Bmpr2^tm1Mmue/Bmpr2⁺ Smad1^tm1Rjle/Smad1⁺
Genetic Background	involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2^tm1Mmue mutation (0 available); any Bmpr2 mutation (45 available)
Smad1^tm1Rjle mutation (0 available); any Smad1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

heart right ventricle hypertrophy ( J:224752 )

• right ventricular hypertrophy by 6 months of age

increased right ventricle systolic pressure ( J:224752 )

• by 6 months of age, mice develop more severe elevations in right ventricular systolic pressure than single Bmpr2 heterozygotes

growth/size/body

heart right ventricle hypertrophy ( J:224752 )

• right ventricular hypertrophy by 6 months of age

muscle

heart right ventricle hypertrophy ( J:224752 )

• right ventricular hypertrophy by 6 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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