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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Relntm1.1Mhat
targeted mutation 1.1, Mitsuharu Hattori
MGI:5774964
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Relntm1.1Mhat/Relntm1.1Mhat B6NSlc.B6(Cg)-Relntm1.1Mhat MGI:5775048


Genotype
MGI:5775048
hm1
Allelic
Composition
Relntm1.1Mhat/Relntm1.1Mhat
Genetic
Background
B6NSlc.B6(Cg)-Relntm1.1Mhat
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relntm1.1Mhat mutation (1 available); any Reln mutation (124 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• the cerebral cortex exhibits normal layer structure
• variably narrower than in wild-type mice starting at P5
• narrower in the presumptive somatosensory cortex than the motor cortex
• the marginal zone and primitive marginal zone is disorganized with blurred borders compared to in wild-type mice
• however, width is normal during embryonic stages and distribution of interneurons is normal
• the dentate granule cell layer is less packed than in wild-type mice
• neurons extend into the marginal zone, first evident at P3
• however, localization of neurons in deeper layer are largely normal

behavior/neurological
N
• unlike the reeler mouse, mice do not exhibit ataxia





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory