All Phenotypes Map1a<m1J> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map1a^m1J/Map1a^m1J	C57BLKS/J-Map1a^m1J/SlacJ	MGI:5774963
ht2	Map1a^m1J/Map1a^{tm1.2(KOMP)Mbp}	involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NJ	MGI:5774961
cx3	Map1a^m1J/Map1a^m1J Tg(Map1a)56Pjn/0	involves: C57BL/6J * C57BLKS/J	MGI:6756405

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:220153 )

N	• mice do not exhibit neuronal death or reactive gliosis in noncerebellar region

abnormal Purkinje cell morphology ( J:220153 )

• reduced microtubule network

Purkinje cell degeneration ( J:220153 )

• at 7 months in the cerebellar cortex and by 18 months in the cerebellum

• transgene expression of the LC2 isoform doesnt not rescue Purkinje cell degeneration

• however, no loss is observed prior to 3 months and transgene expression of the precursor gene rescues Purkinje cell loss

abnormal Purkinje cell dendrite morphology ( J:220153 )

• focal swellings beginning at 6 weeks and becoming more widespread with age

thin cerebellar molecular layer ( J:220153 )

• at 18 months of age

abnormal axon morphology ( J:220153 )

• axonal torpedos beginning at 6 weeks of age

abnormal axon initial segment morphology ( J:220153 )

• hypertrophic or exhibiting abnormal blebs at 2 months

• transgene expression of the LC2 isoform doesnt not rescue the axon initial segment phenotype

behavior/neurological

ataxia ( J:220153 )

• mild

Allelic Composition	Map1a^m1J/Map1a^{tm1.2(KOMP)Mbp}
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1a^m1J mutation (1 available); any Map1a mutation (109 available)
Map1a^{tm1.2(KOMP)Mbp} mutation (0 available); any Map1a mutation (109 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

Purkinje cell degeneration ( J:220153 )

• by 7 months of age without death of other neurons

Allelic Composition	Map1a^m1J/Map1a^m1J Tg(Map1a)56Pjn/0
Genetic Background	involves: C57BL/6J * C57BLKS/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1a^m1J mutation (1 available); any Map1a mutation (109 available)
Tg(Map1a)56Pjn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:220153 )

N	• Even at 18 months of age no locomotor defects or Purkinje cell loss was found consistent with transgenic rescue of the homozygous mutant phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23