Phenotypes associated with this allele

• Allele Symbol: Scrib^{tm1b(NCOM)Mfgc}
• Allele Name: targeted mutation 1b, Mammalian Functional Genomics Centre
• Allele ID: MGI:5766176
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scrib^tm1b(NCOM)Mfgc/Scrib^tm1b(NCOM)Mfgc	C57BL/6N-Scrib^tm1a(NCOM)Mfgc/Tcp	MGI:5797794
ht2	Scrib^tm1b(NCOM)Mfgc/Scrib^+	C57BL/6N-Scrib^tm1a(NCOM)Mfgc/Tcp	MGI:5797793

Genotype
MGI:5797794

hm1

• Allelic Composition: Scrib^{tm1b(NCOM)Mfgc}/Scrib^{tm1b(NCOM)Mfgc}
• Genetic Background: C57BL/6N-Scrib^{tm1a(NCOM)Mfgc}/Tcp
• Cell Lines: M00024_C_366W_A11

Data Sources

IMPC Data for Scrib

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal pericardium morphology ( J:211773 )

♀

IMPC - TCP

craniofacial

abnormal craniofacial morphology ( J:211773 )

IMPC - TCP

embryo

embryonic growth retardation ( J:211773 )

IMPC - TCP

abnormal embryo size ( J:211773 )

IMPC - TCP

abnormal neural tube closure ( J:211773 )

IMPC - TCP

abnormal placenta size ( J:211773 )

♀

IMPC - TCP

pale yolk sac ( J:211773 )

♀

IMPC - TCP

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - TCP

abnormal embryo size ( J:211773 )

IMPC - TCP

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - TCP

nervous system

abnormal neural tube closure ( J:211773 )

IMPC - TCP

abnormal midbrain morphology ( J:211773 )

IMPC - TCP

abnormal hindbrain morphology ( J:211773 )

IMPC - TCP

vision/eye

abnormal eye morphology ( J:211773 )

IMPC - TCP

Genotype
MGI:5797793

ht2

• Allelic Composition: Scrib^{tm1b(NCOM)Mfgc}/Scrib⁺
• Genetic Background: C57BL/6N-Scrib^{tm1a(NCOM)Mfgc}/Tcp
• Cell Lines: M00024_C_366W_A11

Data Sources

IMPC Data for Scrib

behavior/neurological

abnormal gait ( J:211773 )

♀

IMPC - TCP

homeostasis/metabolism

increased circulating triglyceride level ( J:211773 )

IMPC - TCP

vision/eye

abnormal retina morphology ( J:211773 )

♀

IMPC - TCP