Phenotypes associated with this allele

• Allele Symbol: Gja3^tm1.1Vmb
• Allele Name: targeted mutation 1.1, Viviana M Berthoud
• Allele ID: MGI:5762597
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gja3^tm1.1Vmb/Gja3^tm1.1Vmb	involves: 129 * C57BL/6	MGI:5762599
ht2	Gja3^tm1.1Vmb/Gja3^+	involves: 129 * C57BL/6	MGI:5762600

Genotype
MGI:5762599

hm1

• Allelic Composition: Gja3^tm1.1Vmb/Gja3^tm1.1Vmb
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:227244 )

• concentric rings at 7.7 months

• however, lens size is normal

cataract ( J:227244 )

• at 2 months and thereafter

nuclear cataract ( J:227244 )

• anterior nuclear, composed of small opacities that follow a Y shape

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 14 multiple types		DOID:0110253	OMIM:601885	J:227244

Genotype
MGI:5762600

ht2

• Allelic Composition: Gja3^tm1.1Vmb/Gja3⁺
• Genetic Background: involves: 129 * C57BL/6

vision/eye

abnormal lens morphology ( J:227244 )

• concentric rings at 7.7 months

• however, lens size is normal

cataract ( J:227244 )

• at 4 months in some mice and in all mice at older ages

nuclear cataract ( J:227244 )

• anterior nuclear, composed of small opacities that follow a Y shape

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 14 multiple types		DOID:0110253	OMIM:601885	J:227244