Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hic2Gt(E225A08)1.1Wrst mutation
(0 available);
any
Hic2 mutation
(257 available)
|
|
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hic2Gt(E225A08)1.1Wrst mutation
(0 available);
any
Hic2 mutation
(257 available)
Tg(Mef2c-cre)2Blk mutation
(1 available)
|
|
|
mortality/aging
cardiovascular system
N |
• no heart defects or external phenotype
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hic2Gt(E225A08)1.1Wrst mutation
(0 available);
any
Hic2 mutation
(257 available)
Nkx2-5tm1(cre)Rjs mutation
(1 available);
any
Nkx2-5 mutation
(21 available)
|
|
|
mortality/aging
N |
• no embryonic lethality to E15.5
|
embryo
|
• 19% with mild developmental delay and hemorrhage
|
cardiovascular system
|
• 80% with ventricular septal defects
|
|
• in mice showing developmental delay
|
growth/size/body
|
• 19% with mild developmental delay and hemorrhage
|
muscle
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Hic2Gt(E225A08)1.1Wrst mutation
(0 available);
any
Hic2 mutation
(257 available)
|
|
|
mortality/aging
N |
• no embryonic or perinatal lethality
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hic2Gt(E225A08)1.1Wrst mutation
(0 available);
any
Hic2 mutation
(257 available)
Mesp1tm2(cre)Ysa mutation
(1 available);
any
Mesp1 mutation
(17 available)
|
|
|
mortality/aging
|
• 78% lethality by 21 days of age
|
embryo
N |
• embryos grossly normal to E10.5
|
cardiovascular system
|
• in 38% of E13.5 embryos
|
|
• in 69% of E13.5 embryos
|
|
• 69% with ventricular septal defects in E13.5 embryos
|
|
• in 40% of E13.5 embryos
|
homeostasis/metabolism
muscle
|
• in 38% of E13.5 embryos
|