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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hic2Gt(E225A08)1.1Wrst
gene trap E225A08, 1.1, German Gene Trap Consortium
MGI:5703657
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst involves: 129P2/OlaHsd MGI:5707465
cn2
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst
Tg(Mef2c-cre)2Blk/?
involves: 129P2/OlaHsd MGI:5707469
cn3
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S7/SvEvBrd MGI:5707467
cn4
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129P2/OlaHsd * C57BL/6J * CBA/J MGI:5707466
cn5
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst
Mesp1tm2(cre)Ysa/Mesp1+
involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj MGI:5707468


Genotype
MGI:5707465
hm1
Allelic
Composition
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hic2Gt(E225A08)1.1Wrst mutation (0 available); any Hic2 mutation (257 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• no heart defects




Genotype
MGI:5707469
cn2
Allelic
Composition
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst
Tg(Mef2c-cre)2Blk/?
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hic2Gt(E225A08)1.1Wrst mutation (0 available); any Hic2 mutation (257 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• no embryonic lethality

cardiovascular system
N
• no heart defects or external phenotype




Genotype
MGI:5707467
cn3
Allelic
Composition
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hic2Gt(E225A08)1.1Wrst mutation (0 available); any Hic2 mutation (257 available)
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• no embryonic lethality to E15.5

embryo
• 19% with mild developmental delay and hemorrhage

cardiovascular system
• in 40% of mice
• in 80% of mice
• 80% with ventricular septal defects
• in mice showing developmental delay

growth/size/body
• 19% with mild developmental delay and hemorrhage

muscle
• in 40% of mice




Genotype
MGI:5707466
cn4
Allelic
Composition
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Hic2Gt(E225A08)1.1Wrst mutation (0 available); any Hic2 mutation (257 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• no embryonic or perinatal lethality




Genotype
MGI:5707468
cn5
Allelic
Composition
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst
Mesp1tm2(cre)Ysa/Mesp1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hic2Gt(E225A08)1.1Wrst mutation (0 available); any Hic2 mutation (257 available)
Mesp1tm2(cre)Ysa mutation (1 available); any Mesp1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
N
• embryos grossly normal to E10.5

cardiovascular system
• in 38% of E13.5 embryos
• in 69% of E13.5 embryos
• short atrial septa
• 69% with ventricular septal defects in E13.5 embryos
• in 40% of E13.5 embryos

homeostasis/metabolism
• in 20% of E13.5 embryos

muscle
• in 38% of E13.5 embryos





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory