All Phenotypes Lmna<tm1Rben> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lmna^tm1Rben
targeted mutation 1, Ricardo Benavente
MGI:5695312

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmna^tm1Rben/Lmna^tm1Rben	involves: 129S1/Sv * 129X1/SvJ	MGI:5695532

Allelic Composition	Lmna^tm1Rben/Lmna^tm1Rben
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmna^tm1Rben mutation (0 available); any Lmna mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Small testes and absence of post-meiotic cells in the Lmna^tm1Rben/Lmna^tm1Rben testes

reproductive system

reproductive system phenotype ( J:223056 )

N	• females produce offspring when mated to wild-type males • ovaries are appear normal

abnormal reproductive system morphology ( J:223056 )

azoospermia ( J:223056 )

• no sperm in epididymis

small testis ( J:223056 )

• significantly smaller than controls

abnormal meiosis ( J:223056 )

abnormal chromosomal synapsis ( J:223056 )

• frequent defects in chromosome pairing at pachytene stage

• univalent chromosomes are common, particularly sex chromosomes

• heterologous associations between non-homologous chromosomes

• associations between telomeres

abnormal female meiosis ( J:223056 )

• 32% of oocytes show defective synapsis

• ovaries contain diplotene oocytes by 11 days of age

arrest of male meiosis ( J:223056 )

• post meiotic stages completely absent from seminiferous tubules

• high levels of apoptosis in regions of seminiferous tubules where prophase I gametes are expected

• chromosome bouquet resolution is delayed

• male meiosis arrests in a pachytene-like stage

male infertility ( J:223056 )

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:223056 )

• inefficient or unsuccessful double strand break repair

• particularly disruptive to male meiosis

cellular

azoospermia ( J:223056 )

• no sperm in epididymis

abnormal double-strand DNA break repair ( J:223056 )

• inefficient or unsuccessful double strand break repair

• particularly disruptive to male meiosis

endocrine/exocrine glands

small testis ( J:223056 )

• significantly smaller than controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23