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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fryltm1b(KOMP)Wtsi
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:5692715
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fryltm1b(KOMP)Wtsi/Fryltm1b(KOMP)Wtsi C57BL/6N-Fryltm1b(KOMP)Wtsi/Wtsi MGI:6358010
ht2
 		Fryltm1b(KOMP)Wtsi/Fryl+ C57BL/6N-Fryltm1b(KOMP)Wtsi/Wtsi MGI:6262466


Genotype
MGI:6358010
hm1
Allelic
Composition		 Fryltm1b(KOMP)Wtsi/Fryltm1b(KOMP)Wtsi
Genetic
Background		 C57BL/6N-Fryltm1b(KOMP)Wtsi/Wtsi
Cell Lines EPD0553_3_A01
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fryltm1b(KOMP)Wtsi mutation (1 available); any Fryl mutation (441 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
placenta necrosis ( J:261316 )
• necrotic areas in the placenta at E14.5

mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:261316 )
• fewer than the expected number of fetuses are seen at E14.5, indicating sub-viability at this time

embryo
placenta hemorrhage ( J:261316 )
• hemorrhagic areas/blood pools are seen in the E14.5 placenta
abnormal placenta morphology ( J:261316 )
• reduced cellular density of placenta at E14.5
• fibrotic/necrotic areas in the placenta at E14.5
abnormal placental labyrinth vasculature morphology ( J:261316 )
• labyrinth vascular defect at E14.5
placenta necrosis ( J:261316 )
• necrotic areas in the placenta at E14.5
small placenta ( J:261316 )
• small placenta at E14.5

cardiovascular system
abnormal placental labyrinth vasculature morphology ( J:261316 )
• labyrinth vascular defect at E14.5
placenta hemorrhage ( J:261316 )
• hemorrhagic areas/blood pools are seen in the E14.5 placenta




Genotype
MGI:6262466
ht2
Allelic
Composition		 Fryltm1b(KOMP)Wtsi/Fryl+
Genetic
Background		 C57BL/6N-Fryltm1b(KOMP)Wtsi/Wtsi
Cell Lines EPD0553_3_A01
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fryltm1b(KOMP)Wtsi mutation (1 available); any Fryl mutation (441 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

homeostasis/metabolism




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory