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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nek7M1Btlr
mutation 1, Bruce Beutler
MGI:5690178
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nek7M1Btlr/Nek7M1Btlr C57BL/6J-Nek7M1Btlr MGI:5698501
ht2
 		Nek7M1Btlr/Nek7+ C57BL/6J-Nek7M1Btlr MGI:5698502


Genotype
MGI:5698501
hm1
Allelic
Composition		 Nek7M1Btlr/Nek7M1Btlr
Genetic
Background		 C57BL/6J-Nek7M1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek7M1Btlr mutation (0 available); any Nek7 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system

immune system
immune system phenotype ( J:226677 )
N
• mice exhibit normal macrophages, neutrophils, and other major lymphocyte populations and differentiation and proliferation of bone marrow hematopoietic stem cells and myeloid progenitor cells
abnormal macrophage physiology ( J:226677 )
• decreased pyroptosis of nigericin, ATP or alum-stimulated LPS-primed macrophage
• cyclic AMP levels are increased in Cuties macrophages compared to wild-type macrophages after LPS-priming and nigericin stimulation compared with wild-type cells
• however, pyroptosis response to flagellin, poly(dA:dT) or Escherichia coli- or Citrobacter rodentium-infected is normal
decreased interleukin-1 beta secretion ( J:226677 )
• from ATP- or alum-stimulated LPS-primed macrophages, bone marrow-derived macrophages and bone marrow-derived dendritic cells
• from Escherichia coli- or Citrobacter rodentium-infected macrophages
• however, response to flagellin or poly(dA:dT) is normal
decreased interleukin-18 secretion ( J:226677 )
• however, response to flagellin or poly(dA:dT) is normal
• from nigericin, ATP or alum-stimulated LPS-primed macrophage
• from Escherichia coli- or Citrobacter rodentium-infected macrophages
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:226677 )
• mice treated with recombinant human myelin oligodendrocyte glycoprotein exhibit reduced disease severity, reduced recruitment of lymphocytes, monocyte-microglia and natural killer cells to the spinal cord compared with wild-type mice
decreased inflammatory response ( J:226677 )
• monosodium urate crystal-treated mice exhibit impaired recruitment of total cells, neutrophils and F4/80+ monocytes-macrophages to the peritoneal cavity compared with wild-type mice

growth/size/body
decreased body weight ( J:226677 )
• at 2 months
• however, weight is normal at birth

behavior/neurological
paresis ( J:226677 )
• slight

hematopoietic system
hematopoietic system phenotype ( J:226677 )
N
• mice exhibit normal macrophages, neutrophils, and other major lymphocyte populations and differentiation and proliferation of bone marrow hematopoietic stem cells and myeloid progenitor cells
abnormal macrophage physiology ( J:226677 )
• decreased pyroptosis of nigericin, ATP or alum-stimulated LPS-primed macrophage
• cyclic AMP levels are increased in Cuties macrophages compared to wild-type macrophages after LPS-priming and nigericin stimulation compared with wild-type cells
• however, pyroptosis response to flagellin, poly(dA:dT) or Escherichia coli- or Citrobacter rodentium-infected is normal




Genotype
MGI:5698502
ht2
Allelic
Composition		 Nek7M1Btlr/Nek7+
Genetic
Background		 C57BL/6J-Nek7M1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek7M1Btlr mutation (0 available); any Nek7 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:226677 )
N
• mice exhibit normal macrophages, neutrophils, and other major lymphocyte populations
abnormal macrophage physiology ( J:226677 )
• decreased pyroptosis of nigericin, ATP or alum-stimulated LPS-primed macrophage
• however, pyroptosis response to flagellin, poly(dA:dT) or Escherichia coli- or Citrobacter rodentium-infected is normal
decreased interleukin-1 beta secretion ( J:226677 )
• from ATP- or alum-stimulated LPS-primed macrophages, bone marrow-derived macrophages and bone marrow-derived dendritic cells
• from Escherichia coli- or Citrobacter rodentium-infected macrophages
• however, response to flagellin or poly(dA:dT) is normal
decreased interleukin-18 secretion ( J:226677 )
• from nigericin, ATP or alum-stimulated LPS-primed macrophage
• from Escherichia coli- or Citrobacter rodentium-infected macrophages
• however, response to flagellin or poly(dA:dT) is normal
decreased inflammatory response ( J:226677 )
• monosodium urate crystal-treated mice exhibit impaired recruitment of total cells and neutrophils to the peritoneal cavity compared with wild-type mice

hematopoietic system
hematopoietic system phenotype ( J:226677 )
N
• mice exhibit normal macrophages, neutrophils, and other major lymphocyte populations
abnormal macrophage physiology ( J:226677 )
• decreased pyroptosis of nigericin, ATP or alum-stimulated LPS-primed macrophage
• however, pyroptosis response to flagellin, poly(dA:dT) or Escherichia coli- or Citrobacter rodentium-infected is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory