About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sgms1tm1Jia
targeted mutation 1, Xian-Cheng Jiang
MGI:5662506
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sgms1tm1Jia/Sgms1tm1Jia involves: C57BL/6 MGI:5693567


Genotype
MGI:5693567
hm1
Allelic
Composition
Sgms1tm1Jia/Sgms1tm1Jia
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sgms1tm1Jia mutation (0 available); any Sgms1 mutation (204 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• no changes in plasma lipid levels (total cholesterol, phospholipids, triglycerides)
• plasma ceramide levels similar to controls
• plasma sphingomyelin reduced to 52% of control level
• liver sphingomyelin levels reduced to 36% of control levels
• 65% less sphingomyelin in macrophage cell membranes
• liver ceremide levels decreased to 26% of controls
• liver glucosylceramide levels increased 12X
• liver GM3 levels increased 7X
• 8.5 fold more glucosylceramide and 6.2 fold more GM3 in macrophage cell membranes
• plasma glucosylceramide levels increased 7 fold
• plasma GM3 levels increased 6 fold
• significantly decreased plasma levels of IL-6 after LPS stimulation
• significantly decreased plasma levels of TNF alpha after LPS stimulation

immune system
• significantly decreased plasma levels of IL-6 after LPS stimulation
• significantly decreased plasma levels of TNF alpha after LPS stimulation
• attenuated LPS mediated IL-6 secretion from macrophage
• attenuated LPS mediated TNF alpha secretion from macrophage





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/13/2021
MGI 6.16
The Jackson Laboratory