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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Olfr151tm42(Mc4r)Mom
targeted mutation 42, Peter Mombaerts
MGI:5661034
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Olfr151tm42(Mc4r)Mom/Olfr151tm42(Mc4r)Mom B6;129P2-Olfr151tm42(Mc4r)Mom/MomJ MGI:6155741


Genotype
MGI:6155741
hm1
Allelic
Composition
Olfr151tm42(Mc4r)Mom/Olfr151tm42(Mc4r)Mom
Genetic
Background
B6;129P2-Olfr151tm42(Mc4r)Mom/MomJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olfr151tm42(Mc4r)Mom mutation (1 available); any Olfr151 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• although there is monoallelic expression of this substution allele and the expressed receptor responds to its specific agonist, Ro27-3225, but not OLFR151 agonists, 32% of the olfactory sensory neurons expressing this allele have an immature phenotype, being OMP negative and GAP43 positive
• compared with GFP-tagged endogenous olfactory receptor 151 homozygotes, which show expression on 2928 +/- 152 olfactory sensory neurons, only 1013 +/- 92 olfactory sensory neurons express this substitution allele, and the glomeruli they form are much smaller than those formed by normal OLFR151-expressing olfactory sensory neurons

growth/size/body
• although there is monoallelic expression of this substution allele and the expressed receptor responds to its specific agonist, Ro27-3225, but not OLFR151 agonists, 32% of the olfactory sensory neurons expressing this allele have an immature phenotype, being OMP negative and GAP43 positive
• compared with GFP-tagged endogenous olfactory receptor 151 homozygotes, which show expression on 2928 +/- 152 olfactory sensory neurons, only 1013 +/- 92 olfactory sensory neurons express this substitution allele, and the glomeruli they form are much smaller than those formed by normal OLFR151-expressing olfactory sensory neurons

nervous system
• although there is monoallelic expression of this substution allele and the expressed receptor responds to its specific agonist, Ro27-3225, but not OLFR151 agonists, 32% of the olfactory sensory neurons expressing this allele have an immature phenotype, being OMP negative and GAP43 positive
• compared with GFP-tagged endogenous olfactory receptor 151 homozygotes, which show expression on 2928 +/- 152 olfactory sensory neurons, only 1013 +/- 92 olfactory sensory neurons express this substitution allele, and the glomeruli they form are much smaller than those formed by normal OLFR151-expressing olfactory sensory neurons

respiratory system
• although there is monoallelic expression of this substution allele and the expressed receptor responds to its specific agonist, Ro27-3225, but not OLFR151 agonists, 32% of the olfactory sensory neurons expressing this allele have an immature phenotype, being OMP negative and GAP43 positive
• compared with GFP-tagged endogenous olfactory receptor 151 homozygotes, which show expression on 2928 +/- 152 olfactory sensory neurons, only 1013 +/- 92 olfactory sensory neurons express this substitution allele, and the glomeruli they form are much smaller than those formed by normal OLFR151-expressing olfactory sensory neurons

taste/olfaction
• although there is monoallelic expression of this substution allele and the expressed receptor responds to its specific agonist, Ro27-3225, but not OLFR151 agonists, 32% of the olfactory sensory neurons expressing this allele have an immature phenotype, being OMP negative and GAP43 positive
• compared with GFP-tagged endogenous olfactory receptor 151 homozygotes, which show expression on 2928 +/- 152 olfactory sensory neurons, only 1013 +/- 92 olfactory sensory neurons express this substitution allele, and the glomeruli they form are much smaller than those formed by normal OLFR151-expressing olfactory sensory neurons





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory