Analysis Tools
mortality/aging
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• no viable pups are observed, indicating prenatal lethality
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Allele Symbol Allele Name Allele ID |
Tg(Myh6-Jup*)1Ajm transgene insertion 1, Ali J Marian MGI:5660496 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no viable pups are observed, indicating prenatal lethality
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit similar cardiovascular phenotypes as single Tg(Myh6-Jup*)1Ajm transgenic mice
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• increase in fibroadipocytes in the heart
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• reduced left ventricular fractional shortening
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• increase in left ventricular end diastolic diameter, left ventricular end systolic diameter, and left ventricular mass
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• increase in fibroadipocytes in the heart
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• reduced left ventricular fractional shortening
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| arrhythmogenic right ventricular dysplasia 12 | DOID:0110083 |
OMIM:611528 |
J:192719 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about 10%, 20%, and 60% of mice die at 6, 12, and 24 weeks of age, respectively
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• increase in number of adipocytes in the heart, with predominant distribution in the epicardium and patchy distribution in the myocardium
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• the ventricular/body weight ratio is increased
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• interstitial fibrosis is increased about 2-fold
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• left ventricular fractional shortening is decreased
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• left ventricular end diastolic diameter, end systolic diameter, left ventricular mass are increased
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• electrocardiograms show evidence of supraventricular tachycardia in some mice
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• electrocardiograms show evidence of ventricular arrhythmias
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• electrocardiograms show evidence of third-degree atrioventricular block and atrioventricular dissociation in some mice
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• increase in number of adipocytes in the heart, with predominant distribution in the epicardium and patchy adipocyte distribution in the myocardium
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• cardiac progenitor cells isolated from mutants exhibit enhanced adipogenesis
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• cardiac progenitor cells isolated from mutants exhibit enhanced adipogenesis
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• interstitial fibrosis is increased about 2-fold
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• left ventricular fractional shortening is decreased
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| arrhythmogenic right ventricular dysplasia 12 | DOID:0110083 |
OMIM:611528 |
J:192719 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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