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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Septin7tm1Mgl
targeted mutation 1, Matthia Gaestel
MGI:5660259
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Septin7tm1Mgl/Septin7tm1Mgl involves: 129P2/OlaHsd * C3H * C57BL/6 MGI:5660274
cn2
 		Septin7tm1Mgl/Septin7tm1Mgl
Tg(CD2-icre)4Kio/0 		involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/10 * CBA/Ca MGI:5660277


Genotype
MGI:5660274
cn1
Allelic
Composition		 Septin7tm1Mgl/Septin7tm1Mgl
Genetic
Background		 involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin7tm1Mgl mutation (0 available); any Septin7 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:223786 )
N
• primary mouse embryonic fibroblasts transfected with either adeno- or retrovial vectors expressing cre exhibit normal apoptosis rates
increased cell mass ( J:223786 )
• in primary mouse embryonic fibroblasts transfected with either adeno- or retrovial vectors expressing cre
increased cell nucleus count ( J:223786 )
• in primary mouse embryonic fibroblasts transfected with either adeno- or retrovial vectors expressing cre
abnormal cell cycle ( J:223786 )
• primary mouse embryonic fibroblasts transfected with either adeno- or retrovial vectors expressing cre arrest at G2/M phase in the cell cycle unlike control mice
abnormal mitotic cytokinesis ( J:223786 )
• primary mouse embryonic fibroblasts transfected with either adeno- or retrovial vectors expressing cre exhibit impaired cytokinesis and stalled midbody abscission
• however, expression of stathmin rescues cytokinesis
decreased fibroblast proliferation ( J:223786 )
• in primary mouse embryonic fibroblasts transfected with either adeno- or retrovial vectors expressing cre




Genotype
MGI:5660277
cn2
Allelic
Composition		 Septin7tm1Mgl/Septin7tm1Mgl
Tg(CD2-icre)4Kio/0
Genetic
Background		 involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin7tm1Mgl mutation (0 available); any Septin7 mutation (36 available)
Tg(CD2-icre)4Kio mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:223786 )
N
• mice exhibit normal numbers of peripheral blood cells
• myeloid cells and lymphoid cells exhibit normal cytokinesis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory