Phenotypes associated with this allele

• Allele Symbol: Dyrk1a^tm1Jdc
• Allele Name: targeted mutation 1, John D Crispino
• Allele ID: MGI:5648391
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dyrk1a^tm1Jdc/Dyrk1a^tm1Jdc Tg(Mx1-cre)1Cgn/0	involves: 129/Sv * C57BL/6J * C57BL/6NTac * CBA/J	MGI:5660267

Genotype
MGI:5660267

cn1

• Allelic Composition: Dyrk1a^tm1Jdc/Dyrk1a^tm1Jdc; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129/Sv * C57BL/6J * C57BL/6NTac * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle ( J:223138 )

• a large fraction of pre-B and DP thymocytes remain in the S-G2-M phase rather than moving to G0 phase

• double positive (DP) thymocytes, large pre-B cells, small pre-B cells and granulocytes contain more cells in G2-M following 24 hour pulse than controls

increased T cell apoptosis ( J:223138 )

• 4 fold increase in apoptosis of DP thymocytes

endocrine/exocrine glands

decreased thymocyte number ( J:223138 )

• 5-10 fold reduction in total thymocytes at 2 and 4 weeks following pI:pC administration

hematopoietic system

increased T cell apoptosis ( J:223138 )

• 4 fold increase in apoptosis of DP thymocytes

decreased thymocyte number ( J:223138 )

• 5-10 fold reduction in total thymocytes at 2 and 4 weeks following pI:pC administration

decreased double-positive T cell number ( J:223138 )

• decreased number of DP thymocytes

decreased B cell number ( J:223138 )

• reduced numbers of peripheral blood B cells at 2 and 4 weeks following pI:pC administration

decreased immature B cell number ( J:223138 )

• reduced numbers of immature B cells in bone marrow (IgM⁺ IgD^- B220⁺)

decreased mature B cell number ( J:223138 )

• reduced numbers of mature recirculating B cells in bone marrow(IgM⁺ IgD⁺ B220^hi)

decreased pre-B cell number ( J:223138 )

• 2-3 fold reduction in percentage and absolute number of pre-B cells in bone marrow (IgM^- B220⁺ CD43^low/-)

immune system

increased T cell apoptosis ( J:223138 )

• 4 fold increase in apoptosis of DP thymocytes

decreased thymocyte number ( J:223138 )

• 5-10 fold reduction in total thymocytes at 2 and 4 weeks following pI:pC administration

decreased double-positive T cell number ( J:223138 )

• decreased number of DP thymocytes

decreased B cell number ( J:223138 )

• reduced numbers of peripheral blood B cells at 2 and 4 weeks following pI:pC administration

decreased immature B cell number ( J:223138 )

• reduced numbers of immature B cells in bone marrow (IgM⁺ IgD^- B220⁺)

decreased mature B cell number ( J:223138 )

• reduced numbers of mature recirculating B cells in bone marrow(IgM⁺ IgD⁺ B220^hi)

decreased pre-B cell number ( J:223138 )

• 2-3 fold reduction in percentage and absolute number of pre-B cells in bone marrow (IgM^- B220⁺ CD43^low/-)