Phenotypes associated with this allele

• Allele Symbol: App^tm3.1Tcs
• Allele Name: targeted mutation 3.1, Takaomi C Saido
• Allele ID: MGI:5637817
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	App^tm3.1Tcs/App^tm3.1Tcs	involves: C57BL/6	MGI:5638675
hm2	App^tm3.1Tcs/App^tm3.1Tcs	Not Specified	MGI:6160916
cx3	App^tm3.1Tcs/App^tm3.1Tcs Mapt^tm1.1(MAPT)Tcs/Mapt^tm1.1(MAPT)Tcs	involves: 129S/SvEv * C57BL/6	MGI:6414671
cx4	App^tm3.1Tcs/App^tm3.1Tcs Klk7^tm1(KOMP)Vlcg/Klk7^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:6160918

Genotype
MGI:5638675

hm1

• Allelic Composition: App^tm3.1Tcs/App^tm3.1Tcs
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:212758 )

• mice exhibit impaired memory in the Y-maze test by 6 months of age

hematopoietic system

microgliosis ( J:212758 )

• microgliosis in 9 month old mutants is greater than in 18 month old APP^tm2.1Tcs homozygotes

homeostasis/metabolism

amyloidosis ( J:212758 )

• mice develop aggressive amyloid beta amyloidosis with age, with cortical deposition beginning at 2 months of age

• mice exhibit subcortical amyloidosis after 4 months of age

amyloid beta deposits ( J:212758 )

immune system

microgliosis ( J:212758 )

• microgliosis in 9 month old mutants is greater than in 18 month old APP^tm2.1Tcs homozygotes

nervous system

microgliosis ( J:212758 )

• microgliosis in 9 month old mutants is greater than in 18 month old APP^tm2.1Tcs homozygotes

amyloid beta deposits ( J:212758 )

astrocytosis ( J:212758 )

• astrocytosis in 9 month old mutants is greater than in 18 month old APP^tm2.1Tcs homozygotes

abnormal synapse morphology ( J:212758 )

• synaptic alternations as indicated by loss of synaptophysin and PSD95 immunoreactivity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:212758

Genotype
MGI:6160916

hm2

• Allelic Composition: App^tm3.1Tcs/App^tm3.1Tcs
• Genetic Background: Not Specified

nervous system

amyloid beta deposits ( J:261970 )

• at 1-2 months

astrocytosis ( J:261970 )

• at 6-7 months

homeostasis/metabolism

amyloid beta deposits ( J:261970 )

• at 1-2 months

Genotype
MGI:6414671

cx3

• Allelic Composition: App^tm3.1Tcs/App^tm3.1Tcs; Mapt^{tm1.1(MAPT)Tcs}/Mapt^{tm1.1(MAPT)Tcs}
• Genetic Background: involves: 129S/SvEv * C57BL/6

nervous system

increased neuron apoptosis ( J:278451 )

• mice exhibit similar neuronal cell death as in single App^tm3.1Tcs mutants

amyloid beta deposits ( J:278451 )

• mice exhibit similar amyloid pathology as in single App^tm3.1Tcs mutants

CNS inflammation ( J:278451 )

• mice exhibit similar neuroinflammation as in single App^tm3.1Tcs mutants

cellular

increased neuron apoptosis ( J:278451 )

• mice exhibit similar neuronal cell death as in single App^tm3.1Tcs mutants

homeostasis/metabolism

amyloid beta deposits ( J:278451 )

• mice exhibit similar amyloid pathology as in single App^tm3.1Tcs mutants

immune system

CNS inflammation ( J:278451 )

• mice exhibit similar neuroinflammation as in single App^tm3.1Tcs mutants

Genotype
MGI:6160918

cx4

• Allelic Composition: App^tm3.1Tcs/App^tm3.1Tcs; Klk7^{tm1(KOMP)Vlcg}/Klk7^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

nervous system

amyloid beta deposits ( J:261970 )

• increased 5.6-fold compared with App^tm3.1Tcs homozygotes

homeostasis/metabolism

amyloid beta deposits ( J:261970 )

• increased 5.6-fold compared with App^tm3.1Tcs homozygotes