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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apptm3.1Tcs
targeted mutation 3.1, Takaomi C Saido
MGI:5637817
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Apptm3.1Tcs/Apptm3.1Tcs involves: C57BL/6 MGI:5638675
hm2
Apptm3.1Tcs/Apptm3.1Tcs Not Specified MGI:6160916
cx3
Apptm3.1Tcs/Apptm3.1Tcs
Mapttm1.1(MAPT)Tcs/Mapttm1.1(MAPT)Tcs
involves: 129S/SvEv * C57BL/6 MGI:6414671
cx4
Apptm3.1Tcs/Apptm3.1Tcs
Klk7tm1(KOMP)Vlcg/Klk7tm1(KOMP)Vlcg
involves: C57BL/6NTac MGI:6160918


Genotype
MGI:5638675
hm1
Allelic
Composition
Apptm3.1Tcs/Apptm3.1Tcs
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm3.1Tcs mutation (2 available); any App mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit impaired memory in the Y-maze test by 6 months of age

hematopoietic system
• microgliosis in 9 month old mutants is greater than in 18 month old APPtm2.1Tcs homozygotes

homeostasis/metabolism
• mice develop aggressive amyloid beta amyloidosis with age, with cortical deposition beginning at 2 months of age
• mice exhibit subcortical amyloidosis after 4 months of age

immune system
• microgliosis in 9 month old mutants is greater than in 18 month old APPtm2.1Tcs homozygotes

nervous system
• microgliosis in 9 month old mutants is greater than in 18 month old APPtm2.1Tcs homozygotes
• astrocytosis in 9 month old mutants is greater than in 18 month old APPtm2.1Tcs homozygotes
• synaptic alternations as indicated by loss of synaptophysin and PSD95 immunoreactivity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:212758




Genotype
MGI:6160916
hm2
Allelic
Composition
Apptm3.1Tcs/Apptm3.1Tcs
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm3.1Tcs mutation (2 available); any App mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 1-2 months
• at 6-7 months

homeostasis/metabolism
• at 1-2 months




Genotype
MGI:6414671
cx3
Allelic
Composition
Apptm3.1Tcs/Apptm3.1Tcs
Mapttm1.1(MAPT)Tcs/Mapttm1.1(MAPT)Tcs
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm3.1Tcs mutation (2 available); any App mutation (65 available)
Mapttm1.1(MAPT)Tcs mutation (4 available); any Mapt mutation (423 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit similar neuronal cell death as in single Apptm3.1Tcs mutants
• mice exhibit similar amyloid pathology as in single Apptm3.1Tcs mutants
• mice exhibit similar neuroinflammation as in single Apptm3.1Tcs mutants

cellular
• mice exhibit similar neuronal cell death as in single Apptm3.1Tcs mutants

homeostasis/metabolism
• mice exhibit similar amyloid pathology as in single Apptm3.1Tcs mutants

immune system
• mice exhibit similar neuroinflammation as in single Apptm3.1Tcs mutants




Genotype
MGI:6160918
cx4
Allelic
Composition
Apptm3.1Tcs/Apptm3.1Tcs
Klk7tm1(KOMP)Vlcg/Klk7tm1(KOMP)Vlcg
Genetic
Background
involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm3.1Tcs mutation (2 available); any App mutation (65 available)
Klk7tm1(KOMP)Vlcg mutation (1 available); any Klk7 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased 5.6-fold compared with Apptm3.1Tcs homozygotes

homeostasis/metabolism
• increased 5.6-fold compared with Apptm3.1Tcs homozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/19/2021
MGI 6.17
The Jackson Laboratory