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Allele Symbol Allele Name Allele ID |
Tg(HLA-DRA,HLA-DRB5*0101)hiKito transgene insertion hi, Kouichi Ito MGI:5635424 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop spontaneous autoimmune encephalitis with an incidence of 58.3; onset of disease is around 6 weeks of age
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• mice develop spontaneous autoimmune encephalitis with an incidence of 58.3; onset of disease is around 6 weeks of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice do not develop experimental autoimmune encephalitis following induction with MBP (83-99)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show greater numbers of Th1-, Th17-, and GM-CSF+-expressing CD4 T cells in response to MBP (83-99)
• mice that spontaneously develop EAE have greater numbers of MBP-specific Th1, and GM-CDF+ CD4+ T cells in the CNS during the course of spontaneous EAE
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• in both induced and spontaneous EAE mice
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• in both induced and spontaneous EAE mice
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• mice show an increased production of IFN-gamma, IL-17, and GM-CSF cytokines in response to MBP (83-99)
• mice that spontaneously develop EAE exhibit an increased production of IFN-gamma, IL-7 and GM-CSF cytokines in the CNS
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• in both induced and spontaneous EAE mice
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• in both induced and spontaneous EAE mice
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• mice rarely exhibit experimental autoimmune encephalitis (EAE) when immunized with CFA or pertussis alone, but immunization with MBP (83-99) in CFA with pertussis elicits encephalitis in 90% of mice
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• mice that develop either induced or spontaneous EAE show mild redicultis of the spinal nerve root and mild neuritis of the cranial nerve root in less than 50% of sections examined
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• mice that develop either induced or spontaneous EAE show severe/moderate inflammation in the spinal cord (meningomyelitis), with lesser involvement of the brainstem and infiltrates contain predominantly CD4+ T cells and mononuclear cells, as well as polymorphnuclear leukocytes/granulocytes
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• mice develop spontaneous experimental autoimmune encephalitis (EAE) with an incidence of 4.5%; onset of disease is around 10 weeks of age
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• both induced and spontaneous EAE mice develop ascending motor deficits
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• mice show greater numbers of Th1-, Th17-, and GM-CSF+-expressing CD4 T cells in response to MBP (83-99)
• mice that spontaneously develop EAE have greater numbers of MBP-specific Th1, and GM-CDF+ CD4+ T cells in the CNS during the course of spontaneous EAE
|
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• in both induced and spontaneous EAE mice
|
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• in both induced and spontaneous EAE mice
|
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• mice that develop either induced or spontaneous EAE show severe/moderate inflammation in the spinal cord (meningomyelitis), with lesser involvement of the brainstem and infiltrates contain predominantly CD4+ T cells and mononuclear cells, as well as polymorphnuclear leukocytes/granulocytes
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• mice develop spontaneous experimental autoimmune encephalitis (EAE) with an incidence of 4.5%; onset of disease is around 10 weeks of age
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• both induced and spontaneous EAE mice exhibit swollen axons throughout the spinal cord
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• both induced and spontaneous EAE mice exhibit degenerating neurons throughout the spinal cord
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• both induced and spontaneous EAE mice exhibit loss of axons
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| multiple sclerosis | DOID:2377 |
OMIM:612594 OMIM:612595 OMIM:612596 |
J:189816 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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