Phenotypes associated with this allele

• Allele Symbol: Clcc1^{tm1b(KOMP)Mbp}
• Allele Name: targeted mutation 1b, Mouse Biology Program, UC Davis
• Allele ID: MGI:5635038
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clcc1^tm1b(KOMP)Mbp/Clcc1^tm1b(KOMP)Mbp	B6N(Cg)-Clcc1^tm1b(KOMP)Mbp/2J	MGI:6209551
hm2	Clcc1^tm1b(KOMP)Mbp/Clcc1^tm1b(KOMP)Mbp	B6N(Cg)-Clcc1^tm1b(KOMP)Mbp/2J	MGI:6262152
ht3	Clcc1^tm1b(KOMP)Mbp/Clcc1^+	B6N(Cg)-Clcc1^tm1b(KOMP)Mbp/2J	MGI:6209552
ht4	Clcc1^tm1b(KOMP)Mbp/Clcc1^+	B6N(Cg)-Clcc1^tm1b(KOMP)Mbp/2J	MGI:6262151

Genotype
MGI:6209551

hm1

• Allelic Composition: Clcc1^{tm1b(KOMP)Mbp}/Clcc1^{tm1b(KOMP)Mbp}
• Genetic Background: B6N(Cg)-Clcc1^{tm1b(KOMP)Mbp}/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:265914 )

• embryonic lethality, time not specified

Genotype
MGI:6262152

hm2

• Allelic Composition: Clcc1^{tm1b(KOMP)Mbp}/Clcc1^{tm1b(KOMP)Mbp}
• Genetic Background: B6N(Cg)-Clcc1^{tm1b(KOMP)Mbp}/2J
• Cell Lines: DEPD00577_6_C12

Data Sources

IMPC Data for Clcc1

embryo

abnormal embryo turning ( J:211773 )

IMPC - JAX

embryonic growth retardation ( J:211773 )

IMPC - JAX

abnormal embryo size ( J:211773 )

IMPC - JAX

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - JAX

abnormal embryo size ( J:211773 )

IMPC - JAX

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:6209552

ht3

• Allelic Composition: Clcc1^{tm1b(KOMP)Mbp}/Clcc1⁺
• Genetic Background: B6N(Cg)-Clcc1^{tm1b(KOMP)Mbp}/2J

nervous system

decreased retina cone cell number ( J:265914 )

• reduction in number of cone photoreceptors

vision/eye

abnormal retina morphology ( J:265914 )

• retinas exhibit disarray of the photoreceptor layer

• however, the thickness of the retina overall is maintained

abnormal retina inner nuclear layer morphology ( J:265914 )

• decrease in cell density in the inner nuclear layer

abnormal retina inner plexiform layer morphology ( J:265914 )

• decrease in cell density in the inner plexiform layer

abnormal retina outer nuclear layer morphology ( J:265914 )

• decrease in cell density in the outer nuclear layer

abnormal retina outer plexiform layer morphology ( J:265914 )

• decrease in cell density in the outer plexiform layer

abnormal retina photoreceptor layer morphology ( J:265914 )

• retinas exhibit thinning of the photoreceptor layer with cell dropout in the outer and inner nuclear layer and outer plexiform layer and inner plexiform layer

decreased retina cone cell number ( J:265914 )

• reduction in number of cone photoreceptors

decreased a-wave amplitude ( J:265914 )

• scotopic a-wave amplitude responses are depressed

decreased b-wave amplitude ( J:265914 )

• scotopic b-wave amplitude responses are depressed

• photopic b-wave amplitude is decreased

Genotype
MGI:6262151

ht4

• Allelic Composition: Clcc1^{tm1b(KOMP)Mbp}/Clcc1⁺
• Genetic Background: B6N(Cg)-Clcc1^{tm1b(KOMP)Mbp}/2J
• Cell Lines: DEPD00577_6_C12

Data Sources

IMPC Data for Clcc1

hematopoietic system

increased mean corpuscular hemoglobin concentration ( J:211773 )

IMPC - JAX