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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gnao1tm2.1Rneu
targeted mutation 2.1, Richard R Neubig
MGI:5620501
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gnao1tm2.1Rneu/Gnao1tm2.1Rneu B6.129S-Gnao1tm2.1Rneu MGI:5620502
ht2
Gnao1tm2.1Rneu/Gnao1+ 129S-Gnao1tm2.1Rneu MGI:5620504
ht3
Gnao1tm2.1Rneu/Gnao1+ B6.129S-Gnao1tm2.1Rneu MGI:5620503
ht4
Gnao1tm2.1Rneu/Gnao1+ (C57BL/6J x 129S1/SvImJ)F1 MGI:5620505


Genotype
MGI:5620502
hm1
Allelic
Composition
Gnao1tm2.1Rneu/Gnao1tm2.1Rneu
Genetic
Background
B6.129S-Gnao1tm2.1Rneu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnao1tm2.1Rneu mutation (0 available); any Gnao1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• very few viable homozygotes are seen




Genotype
MGI:5620504
ht2
Allelic
Composition
Gnao1tm2.1Rneu/Gnao1+
Genetic
Background
129S-Gnao1tm2.1Rneu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnao1tm2.1Rneu mutation (0 available); any Gnao1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• Background Sensitivity: 100% of mice on the 129S1/SvImJ background survive more than 1 year compared to premature lethality on a C57BL/6J background

behavior/neurological
N
• Background Sensitivity: female mice show no difference in susceptibility to pentylenetetrazol (PTZ) kindling compared to faster sensitization on a C57BL/6J background




Genotype
MGI:5620503
ht3
Allelic
Composition
Gnao1tm2.1Rneu/Gnao1+
Genetic
Background
B6.129S-Gnao1tm2.1Rneu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnao1tm2.1Rneu mutation (0 available); any Gnao1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice that survive to weaning exhibit lethality starting at around 80 days with about 50% dying by 25 weeks of age
• the 50% that survive to 25 weeks show little further premature lethality
• Background Sensitivity: premature lethality occurs after E18.5 but before 2 weeks of age on the C57BL/6J background but not on a 129S1/SvImJ background

behavior/neurological
• Background Sensitivity: mice exhibit faster sensitization to pentylenetetrazol (PTZ) kindling than controls on the C57BL/6J background but not on a 129S1/SvImJ background

nervous system
• 24-week old female mice exhibit elevated frequency of interictal epileptiform discharges, which occur more frequently during sleep than during wakefulness
• interictal epileptiform discharges frequently occur in runs of 1-3 Hz, but none meet criteria for seizures due to the short duration of discharges of less than 10 seconds
• Background Sensitivity: mice exhibit faster sensitization to pentylenetetrazol (PTZ) kindling than controls on the C57BL/6J background but not on a 129S1/SvImJ background

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
developmental and epileptic encephalopathy 17 DOID:0080450 OMIM:615473
J:216850




Genotype
MGI:5620505
ht4
Allelic
Composition
Gnao1tm2.1Rneu/Gnao1+
Genetic
Background
(C57BL/6J x 129S1/SvImJ)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnao1tm2.1Rneu mutation (0 available); any Gnao1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• Background Sensitivity: no deaths are seen up to 47 weeks of age compared to premature lethality on a congenic C57BL/6J background

behavior/neurological
N
• Background Sensitivity: female mice show no difference in susceptibility to pentylenetetrazol (PTZ) kindling compared to faster sensitization on a congenic C57BL/6J background





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory