Analysis Tools
homeostasis/metabolism
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• glycogen levels are nearly absent in brain extracts
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nervous system
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• at 5 months of age, male mice exhibit normal brain morphology, as shown by histologic analyses of the cortex, cerebellum and hippocampus with neuronal and astrocytic markers
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• glycogen levels are nearly absent in brain extracts
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• analysis of fEPSPs evoked at the hippocampal CA3-CA1 synapse during the learning process in Skinner box modules revealed a significantly smaller change in synaptic strength relative to control mice
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• after a high frequency stimulation session, mice fail to present any significant LTP evoked in the CA3-CA1 synapse on the first recording day, unlike control mice
• LTP values are significantly smaller and shorter lasting than those of control mice
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• in response to paired pulses of increasing intensity, mutant hippocampal pyramidal CA1 neurons exhibit a larger facilitation (greater fEPSP slope) to the second pulse than control mice; however, similar increases in fEPSP slope are evoked by the first pulse
• mice exhibit a significantly larger facilitation to paired pulses, especially at short interpulse intervals
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behavior/neurological
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• mice exhibit significantly impaired performance in an operant conditioning task (Skinner box)
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