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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ikzf1tm3Kge
targeted mutation 3, Katia Georgopoulos
MGI:5617014
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ikzf1tm3Kge/Ikzf1tm3Kge
Tg(CD2-icre)4Kio/? 		involves: C57BL/10 * CBA/Ca MGI:5698879
cn2
 		Ikzf1tm3Kge/Ikzf1tm3Kge
Tg(CD19-cre/ERT2)1Cgn/? 		Not Specified MGI:5698880


Genotype
MGI:5698879
cn1
Allelic
Composition		 Ikzf1tm3Kge/Ikzf1tm3Kge
Tg(CD2-icre)4Kio/?
Genetic
Background		 involves: C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf1tm3Kge mutation (0 available); any Ikzf1 mutation (30 available)
Tg(CD2-icre)4Kio mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell physiology ( J:209927 )
• large pre-B cells fail to differentiate further in culture
• grow better than controls on a bone marrow stroma, 2-10 fold more cells in the cell cycle
• greater colony forming potential on bone marrow stroma than control cells
• pre-B cells unable to migrate in response to CXCL12

neoplasm
increased T cell derived lymphoma incidence ( J:209927 )
• rapid development of T lymphoid neoplasms

immune system
abnormal B cell physiology ( J:209927 )
• large pre-B cells fail to differentiate further in culture
• grow better than controls on a bone marrow stroma, 2-10 fold more cells in the cell cycle
• greater colony forming potential on bone marrow stroma than control cells
• pre-B cells unable to migrate in response to CXCL12

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:209927 )
• rapid development of T lymphoid neoplasms




Genotype
MGI:5698880
cn2
Allelic
Composition		 Ikzf1tm3Kge/Ikzf1tm3Kge
Tg(CD19-cre/ERT2)1Cgn/?
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf1tm3Kge mutation (0 available); any Ikzf1 mutation (30 available)
Tg(CD19-cre/ERT2)1Cgn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell apoptosis ( J:209927 )
• after treatment with PF-562271 (inhibitor of FAK and Ptk26) large pre-B cell apoptosis increases
decreased pre-B cell number ( J:209927 )
• after treatment with PF-562271 (inhibitor of FAK and Ptk26) large pre-B cells rapidly decline in number
absent pre-B cells ( J:209927 )
• circulating pre-B cells are not found

cellular
abnormal B cell apoptosis ( J:209927 )
• after treatment with PF-562271 (inhibitor of FAK and Ptk26) large pre-B cell apoptosis increases

immune system
abnormal B cell apoptosis ( J:209927 )
• after treatment with PF-562271 (inhibitor of FAK and Ptk26) large pre-B cell apoptosis increases
decreased pre-B cell number ( J:209927 )
• after treatment with PF-562271 (inhibitor of FAK and Ptk26) large pre-B cells rapidly decline in number
absent pre-B cells ( J:209927 )
• circulating pre-B cells are not found




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory